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Delivery of Thrombospondin-2 Small Interfering RNA for Suppression of Intimal Hyperplasia
Treatments of peripheral arterial disease, which affects>8.5 million individuals in the United States, include angioplasty and stenting and graft bypass. However, these have been limited by the pervasive development of intimal hyperplasia, which leads to in-stent restenosis and reduced graft patency. We propose a novel technique to suppress the progression of intimal hyperplasia using bioengineered hydrogels (ClickGels) for localized small interfering RNA (siRNA) delivery and suppression of thrombospondin-2 (TSP2), an upregulated gene of intimal hyperplasia, in an in vivo rat carotid angioplasty model.
Source: Journal of Vascular Surgery - August 24, 2021 Category: Surgery Authors: Jennifer R. Li, Kimberly Piper, Patric Liang, Max Zhu, Mauricio Contreras, Alexander Stafford, David Mooney, Leena Pradhan-Nabzdyk, Frank Logerfo Tags: PC: Poster Competition Source Type: research