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Lipoteichoic acid upregulates plasminogen activator inhibitor ‐1 expression in parapneumonic effusions
ConclusionCulture‐positive PPE, especially that caused by GPB, has a significantly higher level of PAI‐1 than uncomplicated CN PPE. LTA upregulates PAI‐1 expression through activation of TLR2/JNK/activator protein 1 (AP‐1) pathway in human PMC. Better understanding of the modulation of PAI‐1 synthesis by LTA in PPE may provide potential therapies for infected pleural effusions.
Source: Respirology - August 23, 2017 Category: Respiratory Medicine Authors: Kai ‐Ling Lee, Wei‐Lin Chen, Ray‐Jade Chen, Kevin S. Lai, Chi‐Li Chung Tags: Original Article Source Type: research

Role of the PKC α‐c‐Src tyrosine kinase pathway in the mediation of p120‐catenin degradation in ventilator‐induced lung injury
ConclusionThe current findings demonstrate that PKCα and c‐Src kinase participate in VILI. PKCα activation phosphorylates c‐Src kinase and further decreases p120‐catenin in VILI.
Source: Respirology - July 27, 2016 Category: Respiratory Medicine Authors: Tao Zhao, Hongwei Zhao, Gang Li, Shengfa Zheng, Mengjie Liu, Changping Gu, Yuelan Wang Tags: Original Article Source Type: research

Reduced transforming growth factor β1 (TGF‐β1) in the repair of airway epithelial cells of children with asthma
ConclusionOur data has highlighted the importance of TGF‐β1 in pAEC wound repair in vitro. The significantly lower levels seen in asthmatic pAEC subsequently contributes to the dysregulated repair observed in these cells.
Source: Respirology - May 23, 2016 Category: Respiratory Medicine Authors: Kak‐Ming Ling, Erika N. Sutanto, Thomas Iosifidis, Elizabeth Kicic‐Starcevich, Kevin Looi, Luke W. Garratt, Kelly M. Martinovich, Francis J. Lannigan, Darryl A. Knight, Stephen M. Stick, Anthony Kicic Tags: Original Article Source Type: research