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Deoxyarbutin attenuates severe acute pancreatitis via the HtrA2/PGC-1 α pathway
Free Radic Res. 2023 Jan 2:1-15. doi: 10.1080/10715762.2022.2163244. Online ahead of print.ABSTRACTSevere acute pancreatitis (SAP) is an inflammatory disorder of the exocrine pancreas associated with high morbidity and mortality. SAP has been proven to trigger mitochondria dysfunction in the pancreas. We found that Deoxyarbutin (dA) recovered impaired mitochondrial function. High-temperature requirement protein A2 (HtrA2), a mitochondrial serine protease upstream of PGC-1α, is charge of quality control in mitochondrial homeostasis. The molecular docking study indicated that there was a potential interaction between dA and...
Source: Free Radical Research - January 2, 2023 Category: Research Authors: Yangying Li Yuda Zhu Shiyi Li Yuman Dong Chengyu Wan Xiuxian Yu Guang Xin Zeliang Wei Fan Li Yilan Wang Kun Zhang Qingqiu Chen Cuicui Zhang E Wen Hai Niu Wen Huang Source Type: research

VDR promotes nucleus pulposus cell mitophagy as a protective mechanism against oxidative stress injury
This study demonstrates that VDR activation ameliorates oxidative damage and decreases NP cell apoptosis by promoting PINK1/Parkin-dependent mitophagy, indicating that VDR may serve as a promising therapeutic target in the management of IDD.PMID:35786375 | DOI:10.1080/10715762.2022.2094791
Source: Free Radical Research - July 5, 2022 Category: Research Authors: Tao Lan Bin Yan Weizhuang Guo Zhe Shen Jianting Chen Source Type: research

Upregulation of p67 < sup > phox < /sup > in response to ischemia/reperfusion is cardioprotective by increasing ZIP2 expression via STAT3
In conclusion, an increase of p67phox expression in response to Zn2+ is an intrinsic adaptive response to I/R and leads to cardioprotection against I/R by upregulating ZIP2 via STAT3.PMID:35296207 | DOI:10.1080/10715762.2022.2052057
Source: Free Radical Research - March 17, 2022 Category: Research Authors: Liang Zhao Rui Zhang Shuya Zhang Hualu Zhang Qing Yang Zhelong Xu Source Type: research

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