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B7-H3 on breast cancer cell MCF7 inhibits IFN- γ release from tumour-infiltrating T cells
Pathol Res Pract. 2021 May 5;224:153461. doi: 10.1016/j.prp.2021.153461. Online ahead of print.ABSTRACTB7-H3 is a type I membrane protein that has contradictory co-stimulatory and co-inhibitory effects in adaptive and anti-tumour immunity. B7-H3 is up-regulated in many malignant tumours, including breast cancer. Therefore, we hypothesise that B7-H3, which has an immunosuppressive role, suppresses anti-tumour immunity. The aim of this study was to clarify the role of B7-H3 in the tumor microenvironment in breast cancer, explore the possibility of B7-H3 as a target for clinical immunotherapy, and provide reference for clinic...
Source: Pathology, Research and Practice - July 15, 2021 Category: Pathology Authors: Lili Shao Qiongzhu Yu Rui Xia JiaYu Zhang Siyi Gu Daojiang Yu Zhixiang Zhuang Source Type: research

Preclinical Safety Evaluation in Rats of a Polymeric Matrix Containing an siRNA Drug Used as a Local and Prolonged Delivery System for Pancreatic Cancer Therapy.
We describe the safety and toxicity studies with siG12D-LODER in 192 Hsd:Sprague Dawley rats, after repeated subcutaneous administrations (days 1, 14, and 28). Animals were sacrificed on days 29 and 42 (recovery phase). In all groups, no adverse effects were noted, and all animals showed favorable local and systemic tolerability. Histopathologically, LODER implantation resulted in the expected capsule formation, composed of a thin fibrotic tissue. On the interface between the cavity and the capsule, a single layer composed of macrophages and multinucleated giant cells was observed. No difference was noted between the place...
Source: Toxicologic Pathology - May 3, 2016 Category: Pathology Authors: Ramot Y, Rotkopf S, Gabai RM, Khvalevsky EZ, Muravnik S, Marzoli GA, Domb AJ, Shemi A, Nyska A Tags: Toxicol Pathol Source Type: research