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Specialty: Pathology
Infectious Disease: Hepatitis C
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Total 1 results found since Jan 2013.
HCV Infection Selectively Impairs Type I but Not Type III IFN Signaling.
Abstract
A stable and persistent Hepatitis C virus (HCV) replication cell culture model was developed to examine clearance of viral replication during long-term treatment using interferon-α (IFN-α), IFN-λ, and ribavirin (RBV). Persistently HCV-infected cell culture exhibited an impaired antiviral response to IFN-α+RBV combination treatment, whereas IFN-λ treatment produced a strong and sustained antiviral response that cleared HCV replication. HCV replication in persistently infected cells induced chronic endoplasmic reticulum (ER) stress and an autophagy response that selectively down-regulated the functiona...
Source: The American Journal of Pathology - November 8, 2013 Category: Pathology Authors: Chandra PK, Bao L, Song K, Aboulnasr FM, Baker DP, Shores N, Wimley WC, Liu S, Hagedorn CH, Fuchs SY, Wu T, Balart LA, Dash S Tags: Am J Pathol Source Type: research
