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Zinc-finger transcription factor Odd - skipped related 1 regulates cranial bone formation
AbstractKnowledge of the molecular mechanisms of bone formation has been advanced by novel findings related to genetic control.Odd-skipped related 1 (Osr1) is known to play important roles in embryonic, heart, and urogenital development. To elucidate the in vivo function ofOsr1 in bone formation, we generated transgenic mice overexpressing full-lengthOsr1 under control of its 2.8-kb promoter, which were smaller than their wild-type littermates. Notably, abnormalities in the skull ofOsr1 transgenic mice were revealed by analysis of X-ray, skeletal preparation, and morphological findings, including round skull and cranial dy...
Source: Journal of Bone and Mineral Metabolism - December 12, 2017 Category: Orthopaedics Source Type: research