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Evaluation of the Effect of (S)-3,4-Dicarboxyphenylglycine as a Metabotropic Glutamate Receptors Subtype 8 Agonist on Thermal Nociception Following Central Neuropathic Pain.
Conclusions: The results revealed that activation of mGluR8 in PAG is not capable of improving the thermal hyperalgesia threshold. Based on the decreased expression of mGluR8 after SCI induced by clip compression injury and its significant increase after treatment of siRNA against mGluR8, this method might still hold promise as an effective treatment of neuropathic pain. It can be concluded that increased expression of mGluR8 is due to the fact that DCPG prevents the death of neurons that express these receptors. PMID: 32460469 [PubMed - as supplied by publisher]
Source: Asian Spine Journal - May 29, 2020 Category: Orthopaedics Tags: Asian Spine J Source Type: research

MiR-25 protects PC-12 cells from H2O2 mediated oxidative damage via WNT/ β-catenin pathway.
CONCLUSIONS: miR-25 protects PC-12 cells against H2O2-induced oxidative damage though regulation of Nrf2 and activation of Wnt/β-catenin and PI3 K/AKT/ERK signaling. PMID: 28605990 [PubMed - as supplied by publisher]
Source: Journal of Spinal Cord Medicine - June 15, 2017 Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research