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PEG10 counteracts signaling pathways of TGF- β and BMP to regulate growth, motility and invasion of SW1353 chondrosarcoma cells
AbstractRecently, we reported highly active transforming growth factor (TGF)- β and bone morphogenetic protein (BMP) signaling in human chondrosarcoma samples and concurrent downregulation of paternally expressed gene 10 (PEG10). PEG10 expression was suppressed by TGF- β signaling, and PEG10 interfered with the TGF-β and BMP-SMAD pathways in chondrosarcoma cells. However, the roles of PEG10 in bone tumors, including chondrosarcoma, remain unknown. Here, we report that PEG10 promotes SW1353 chondrosarcoma cell growth by preventing TGF-β1-mediated suppression. In contrast, PEG10 knockdown augments the TGF-β1-induced mot...
Source: Journal of Bone and Mineral Metabolism - August 9, 2018 Category: Orthopaedics Source Type: research

Histone deacetylase 4 alters cartilage homeostasis in human osteoarthritis
Conclusions: In this study, our findings suggest that the abnormal expression of HDAC4 in osteoarthritic cartilage might be implicated in promoting catabolic activity of chondrocyte, which is associated with OA pathogenesis. Thus, our findings give a new insight into the mechanism of articular cartilage damage, and indicate that HDAC4 might be a potential target for the therapeutic interventions of OA.
Source: BMC Musculoskeletal Disorders - December 17, 2014 Category: Orthopaedics Authors: Jingwei LuYe SunQiting GeHuajian TengQing Jiang Source Type: research

MicroRNA Regulates Vascular Endothelial Growth Factor Expression in Chondrosarcoma Cells.
CONCLUSIONS: miR-181a is a hypoxia-regulated microRNA that is overexpressed in chondrosarcoma and enhances VEGF expression, an effect that could be inhibited by anti-miR-181a. CLINICAL RELEVANCE: Systemic treatment options for chondrosarcoma are limited. Antiangiogenic strategies could potentially be effective in limiting tumor progression. One method of inhibiting VEGF expression and associated angiogenesis could be an antagomir-based therapy targeted at miR-181a or other oncogenic microRNAs, although methods of systemic delivery are still under development. The effectiveness of antagomirs also needs to be compared w...
Source: Clinical Orthopaedics and Related Research - August 9, 2014 Category: Orthopaedics Authors: Sun X, Wei L, Chen Q, Terek RM Tags: Clin Orthop Relat Res Source Type: research