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Complement 3a Mediates CCN2/CTGF in Human Retinal Pigment Epithelial Cells
CONCLUSIONS: C3 was elevated in RPE under environmental stimulus and long-term exposure to specified concentration of C3a increased CCN2/CTGF expression in RPE, which could be partially reversed by C3 siRNA.PMID:36276919 | PMC:PMC9581697 | DOI:10.1155/2022/3259453
Source: Journal of Ophthalmology - October 24, 2022 Category: Opthalmology Authors: Kang Xiao Zhiyan Xu Zhengyu Chen Qin Long Youxin Chen Source Type: research

In Vitro Screening and Transfection Concentration Optimization of Cynomolgus Monkey I κBα-siRNA.
Conclusion: It proves that the siRNA targeting the GCACTTAGCCTCTATCCAT of IκBα gene is the valid sequence to suppress cynomolgus monkey IκBα expression of CM cells and TM cells by RNAi. 10 nM is the optimal transfection concentration. PMID: 32377413 [PubMed]
Source: Journal of Ophthalmology - May 8, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Clinical Role of Epigenetics and Network Analysis in Eye Diseases: A Translational Science Review.
Authors: Lanza M, Benincasa G, Costa D, Napoli C Abstract Network medicine is a molecular-bioinformatic approach analyzing gene-gene interactions that can perturb the human interactome. This review focuses on epigenetic changes involved in several ocular diseases, such as DNA methylation, histone and nonhistone post-translational modifications, and noncoding RNA regulators. Although changes in aberrant DNA methylation play a major role in the pathogenesis of most ocular diseases, histone modifications are seldom investigated. Hypermethylation in TGM-2 and hypomethylation in MMP-2/CD24 promoter genes may play a cruc...
Source: Journal of Ophthalmology - January 25, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Knockdown of Fibromodulin Inhibits Proliferation and Migration of RPE Cell via the VEGFR2-AKT Pathway.
Conclusion: Depletion of FMOD selectively downregulated the expression of VEGF and VEGFR2 and inhibited the signaling pathway of AKT phosphorylation, which consequently inhibited the proliferation and migration of RPE Cell. PMID: 30298106 [PubMed]
Source: Journal of Ophthalmology - October 10, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research