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Current treatments for corneal neovascularization.
Authors: Benayoun Y, Petellat F, Leclerc O, Dost L, Dallaudière B, Reddy C, Robert PY, Salomon JL Abstract The extension of blood vessels into the normally avascular stroma defines corneal neovascularization. Though this phenomenon, pathophysiological and clinical features are well characterized, therapeutic modalities have been hindered by a lack of safe, efficacious and non-controversial treatments. In this literature review, we focus on available therapeutic options in light of recent evidence provided by animal and clinical studies. First, this review will focus on pharmacological treatments that target angiog...
Source: Journal Francais d Ophtalmologie - November 28, 2015 Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research

Modulation of Bevacizumab-Induced Toxicity for Cultured Human Corneal Fibroblasts Cornea
Conclusions. This study determined the cellular toxicity of bevacizumab and its modulation with bFGF or NGF. Cotreatment with bFGF or NGF with bevacizumab reduced cellular damage without interfering with the original antiangiogenic function. Some components of serum have a protective effect on bevacizumab-induced corneal epithelial change.
Source: Investigative Ophthalmology - June 6, 2013 Category: Opthalmology Authors: Kim, E. K., Kang, S. W., Kim, J. Y., Min, K., Kim, T.-i. Tags: Cornea Source Type: research