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Minocycline prevents the inflammatory response after retinal detachment, where microglia phenotypes being regulated through A20.
Abstract Retinal detachment (RD) is a severe sight-threatening complication that can be caused by a multitude of retinal diseases. It has been evidenced that minocycline exerts neuroprotective effects by targeting microglia in the pathogenesis of massive ocular lesions including RD, but mechanisms remain elusive. We carried out this research to elucidate the potential mediators that link RD-induced vision loss with microglia reactivity by discussing effects of minocycline on cytokine levels and A20, a negative regulator of inflammation. Minocycline or vehicle was intraperitoneally administrated immediately after R...
Source: Experimental Eye Research - December 13, 2020 Category: Opthalmology Authors: Gao W, Du J, Chi Y, Zhu R, Gao X, Yang L Tags: Exp Eye Res Source Type: research