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Specialty: Opthalmology
Drug: Donepezil
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Total 1 results found since Jan 2013.
Inhibition of acetylcholinesterase attenuated retinal inflammation via suppressing NF- κB activation.
This study was aimed to dissect the role of ACHE in retinal inflammation, and its mechanism of action. Retinal inflammation was induced by intravitreal injection of tumor necrosis factor-α (TNF-α) in heterozygous ACHE knockout mice (ACHE+/-) and wild type mice (ACHE+/+). Donepezil, a well-known ACHE inhibitor, was administrated by daily gavage. Expression of ACHE and intercellular adherent molecule-1 (ICAM-1), infiltration of CD11b+ inflammatory cells, retinal leukostasis and vascular leakage was determined in both ACHE ± and ACHE+/+ mice. ARPE-19 cells, a human retinal pigment epithelial cell line, were cultured for ...
Source: Experimental Eye Research - March 13, 2020 Category: Opthalmology Authors: Li J, Chen Y, Zhang X, Ye S, Yi J, Chen Q, Liu Q Tags: Exp Eye Res Source Type: research
