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Specialty: Opthalmology
Condition: Multidrug Resistance
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Total 2 results found since Jan 2013.
Up-regulation of P-gp via NF- κB activation confers protection against oxidative damage in the retinal pigment epithelium cells.
In conclusion, P-gp can provide moderate cytoprotection for the human RPE cells by ameliorating the mitochondrial dysfunction and NF-κB activation may be a potential regulator of P-gp expression response to oxidative stress.
PMID: 30496729 [PubMed - as supplied by publisher]
Source: Experimental Eye Research - November 26, 2018 Category: Opthalmology Authors: Feng Q, Yang W, Gao Z, Ruan X, Zhang Y Tags: Exp Eye Res Source Type: research
MRP4-Mediated Regulation of Intracellular cAMP and cGMP Levels in Trabecular Meshwork Cells and Homeostasis of Intraocular Pressure Physiology and Pharmacology
Conclusions.
These observations reveal that cyclic nucleotide efflux controlling transporter-MRP4 plays a significant role in IOP homeostasis potentially by regulating the relaxation characteristics of AH outflow pathway cells.
Source: Investigative Ophthalmology - March 5, 2013 Category: Opthalmology Authors: Pattabiraman, P. P., Pecen, P. E., Rao, P. V. Tags: Physiology and Pharmacology Source Type: research
