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Dengue virus induces Interferon- β by activating RNA sensing pathways in megakaryocytes
Immunol Lett. 2021 Jun 7:S0165-2478(21)00095-X. doi: 10.1016/j.imlet.2021.06.001. Online ahead of print.ABSTRACTActivation of innate receptors in megakaryocytes (MKs) may affect the ability to produce functional platelets. Low platelet count is one of the clinical manifestations of dengue virus (DENV) infection. In MKs, the effect of innate receptors during DENV-infection is not well studied. Here we used MEG-01 cells to investigate DENV serotype 2 induced innate receptors in these cells. DENV RNA was estimated by qRT-PCR in the culture supernatant. The expression of innate receptors was determined by western blot and qPCR...
Source: Immunology Letters - June 10, 2021 Category: Allergy & Immunology Authors: Ravi Prakash Arya Anismrita Lahon Ashok Kumar Patel Source Type: research

Dengue virus induces interferon- β by activating RNA sensing pathways in megakaryocytes
Immunol Lett. 2021 Jun 7;236:31-36. doi: 10.1016/j.imlet.2021.06.001. Online ahead of print.ABSTRACTActivation of innate receptors in megakaryocytes (MKs) may affect the ability to produce functional platelets. Low platelet count is one of the clinical manifestations of dengue virus (DENV) infection. In MKs, the effect of innate receptors during DENV-infection is not well studied. Here we used MEG-01 cells to investigate DENV serotype 2 induced innate receptors in these cells. DENV RNA was estimated by qRT-PCR in the culture supernatant. The expression of innate receptors was determined by western blot and qPCR. DENV infec...
Source: Immunology Letters - June 10, 2021 Category: Allergy & Immunology Authors: Ravi Prakash Arya Anismrita Lahon Ashok Kumar Patel Source Type: research

Dengue virus induces Interferon- β by activating RNA sensing pathways in megakaryocytes
Immunol Lett. 2021 Jun 7:S0165-2478(21)00095-X. doi: 10.1016/j.imlet.2021.06.001. Online ahead of print.ABSTRACTActivation of innate receptors in megakaryocytes (MKs) may affect the ability to produce functional platelets. Low platelet count is one of the clinical manifestations of dengue virus (DENV) infection. In MKs, the effect of innate receptors during DENV-infection is not well studied. Here we used MEG-01 cells to investigate DENV serotype 2 induced innate receptors in these cells. DENV RNA was estimated by qRT-PCR in the culture supernatant. The expression of innate receptors was determined by western blot and qPCR...
Source: Immunology Letters - June 10, 2021 Category: Allergy & Immunology Authors: Ravi Prakash Arya Anismrita Lahon Ashok Kumar Patel Source Type: research

IFIT5 Participates in the Antiviral Mechanisms of Rainbow Trout Red Blood Cells
We described a new defense mechanism based on IFIT5 antiviral activity in nucleated RBCs that appeared to contribute to halting the VHSV infection. This finding sheds light into novel antiviral therapeutics to mitigate the economic losses and social impact caused by viral infections in the aquaculture industry. This work broadens the knowledge of fish nucleated RBCs functions and their role in the immune response to viral infections. Ethics Statement Experimental protocols and methods relating to experimental animals were reviewed and approved by the Animal Welfare Body and the Research Ethics Committee at the University...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research