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HOTAIR knockdown impairs metastasis of cervical cancer cells by down-regulating metastasis-related genes
This study investigated the role of LncRNA HOTAIR knockdown in the biological impacts on cervical cancer cells. The HOTAIR gene in two human cervical cancer cell lines was silenced with small interfering (si) RNA siHOTAIR. Proliferation, apoptosis, migration and invasion of cells were assessed following the knockdown. The expressions of Notch1, EpCAM, E-cadherin, vimentin and STAT3 were assessed using qRT-PCR and Western blotting analysis. Compared with controls, HOTAIR levels were reduced significantly, the OD values of cells were significantly decreased in proliferation assays, cell apoptosis was significantly increased,...
Source: Journal of Obstetrics and Gynaecology - March 27, 2023 Category: OBGYN Authors: Lei Shi Dehui Zhang Huijuan Han Liangyu Zhang Sirui Li Fang Yang Caijun He Source Type: research