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Effect of HSP10 on apoptosis induced by testosterone in cultured mouse ovarian granulosa cells
Abstract: Objective: To investigate the effect of heat shock protein 10 (HSP10) on apoptosis induced by testosterone in granulosa cells (GCs) of mouse ovaries in order to define the possible roles of HSP10 in ovarian pathological development of polycystic ovarian syndrome (PCOS) and hyperandrogenic conditions.Study design: Cultured mouse ovarian GCs were treated with testosterone (10−5mol/l). Apoptosis was assessed using flow cytometry, and proliferation was assessed using the MTT assay. HSP10 expression in the treated GCs was detected by real-time polymerase chain reaction (PCR). HSP10 gene was downregulated in the cult...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - October 7, 2013 Category: OBGYN Authors: Kao-Kao Zhao, Yu-Gui Cui, Ya-Qin Jiang, Jing Wang, Mei Li, Yuan Zhang, Xiang Ma, Fei-Yang Diao, Jia-Yin Liu Tags: Reproductive Medicine and Endocrinology Source Type: research

Simultaneous suppression of Src and signal transducer and activator of transcription 3 inhibits the growth of epithelial ovarian cancer cells
Conclusions: This study has demonstrated the principle that the simultaneous suppression of c-Src and STAT3 inhibits the growth of epithelial ovarian cancer cells and seems to enhance the cytotoxicity of chemotherapeutic agents in ovarian cancer.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 14, 2013 Category: OBGYN Authors: Shin-Wha Lee, Jin Yoo, Soo-Hyoung Lee, Dongho Kim, Yong-Man Kim, Young-Tak Kim Tags: Gynecology and Gynecological Oncology Source Type: research