• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Increased Expression of S100B and RAGE in a Mouse Model of Bile Duct Ligation-induced Liver Fibrosis
CONCLUSION: These findings suggest that the increased expression of S100B and RAGE and the interaction between S100B and RAGE may play an important role in ductular reaction and liver fibrosis induced by BDL.PMID:33847081 | DOI:10.3346/jkms.2021.36.e90
Source: J Korean Med Sci - April 13, 2021 Category: General Medicine Authors: Ji Won Park Mo Jong Kim Sung Eun Kim Hee Jun Kim Yong Chul Jeon Hae Young Shin Se Jin Park Myoung Kuk Jang Dong Joon Kim Choong Kee Park Eun Kyoung Choi Source Type: research

Bilirubin Activates Transcription of HIF-1α in Human Proximal Tubular Cells Cultured in the Physiologic Oxygen Content.
Abstract The expression of hypoxia-inducible factor (HIF) is influenced by reactive oxygen species (ROS). Effect of bilirubin on HIF-1 expression in proximal tubular cells was investigated under physiological oxygen concentration, which is relative hypoxic condition mimicking oxygen content in the medulla of renal tissue. The human kidney (HK2) cells were cultured in 5% oxygen with or without bilirubin. HIF-1α protein expression was increased by bilirubin treatment at 0.01-0.2 mg/dL concentration. The messenger RNA expression of HIF-1α was increased by 1.69±0.05 folds in the cells cultured with 0.1 mg/dL biliru...
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Kim SG, Ahn SY, Lee ES, Kim S, Na KY, Chae DW, Chin HJ Tags: J Korean Med Sci Source Type: research

Cobalt Chloride Attenuates Oxidative Stress and Inflammation through NF-κB Inhibition in Human Renal Proximal Tubular Epithelial Cells.
Abstract We evaluated the effect of cobalt chloride (CoCl2) on TNF-α and IFN-γ-induced-inflammation and reactive oxygen species (ROS) in renal tubular epithelial cells (HK-2 cells). We treated HK-2 cells with CoCl2 before the administration of TNF-α/IFN-γ. To regulate hemeoxygenase-1 (HO-1) expression, the cells were treated CoCl2 or HO-1 siRNA. CoCl2 reduced the generation of ROS induced by TNF-α/IFN-γ. TNF-α/IFN-γ-treated-cells showed an increase in the nuclear translocation of phosphorylated NF-κBp65 protein, the DNA-binding activity of NF-κBp50 and NF-κB transcriptional activity and a decrease in IÎ...
Source: J Korean Med Sci - September 1, 2014 Category: Journals (General) Authors: Oh SW, Lee YM, Kim S, Chin HJ, Chae DW, Na KY Tags: J Korean Med Sci Source Type: research