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MicroRNA-490-3p suppresses hepatocellular carcinoma cell proliferation and migration by targeting the aurora kinase A gene (AURKA).
Conclusions: miR-490-3p could down-regulate the expression of AURKA, thus suppressing the proliferation and migration of HCC cells. PMID: 32190151 [PubMed]
Source: Archives of Medical Science - March 20, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

The effect of miR-124-3p on cell proliferation and apoptosis in bladder cancer by targeting EDNRB.
Conclusions: miR-124-3p regulates the proliferation and apoptosis of BC cells by suppressing EDNRB expression. PMID: 31572460 [PubMed]
Source: Archives of Medical Science - October 2, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Suppression of the long non-coding RNA MALAT-1 impairs the growth and migration of human tongue squamous cell carcinoma SCC4 cells.
Conclusions: Elevated expression of MALAT-1 in OSCC may play a role in tumorigenesis and/or metastasis. Further studies are necessary to identify the mechanism by which MALAT-1 influences SCC4 growth and migration and validate its increased expression in OSCC patients. PMID: 31360193 [PubMed]
Source: Archives of Medical Science - August 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

BDNF contributes to the skeletal muscle anti-atrophic effect of exercise training through AMPK-PGC1 α signaling in heart failure mice.
Conclusions: Taken together, our data provide evidence for exercise training may counteract HF-induced muscle atrophy through induced activation of BDNF pathway. PMID: 30697273 [PubMed]
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Trichostatin A activates FOXO1 and induces autophagy in osteosarcoma.
Conclusions: We found that inhibition of autophagy, either by autophagy inhibitors or ATG gene knockdown, markedly enhances TSA-caused cell death. Taken together, our studies reveal the function of autophagy in HDACI-caused osteosarcoma cell death and thus support the development of a novel therapeutic strategy by combining HDACIs and autophagy inhibitors in osteosarcoma treatment. PMID: 30697272 [PubMed]
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Exosomes as nanocarriers for siRNA delivery: paradigms and challenges.
Authors: Shahabipour F, Banach M, Sahebkar A Abstract Exosomes are nano-sized vesicles that facilitate intercellular communications through carrying genetic materials and functional biomolecules. Owing to their unique size and structure, exosomes have emerged as a useful tool to overcome the limitations of siRNA delivery. The use of exosomes as siRNA delivery vehicles lacks certain disadvantages of the existing foreign delivery systems such as viruses, polycationic polymers and liposomes, and introduces several advantages including inherent capacity to pass through biological barriers and escape from phagocytosis b...
Source: Archives of Medical Science - December 3, 2016 Category: Journals (General) Tags: Arch Med Sci Source Type: research

NLRP3 inflammasome: a novel link between lipoproteins and atherosclerosis.
CONCLUSIONS: The data suggest that activation of the NLRP3 inflammasome is a critical step in caspase-1 activation and IL-1β and IL-18 secretion. Interference with the NLRP3 inflammasome can significantly inhibit the generation of cytokines, thus impeding the pathogenesis of inflammation. PMID: 27695484 [PubMed - in process]
Source: Archives of Medical Science - October 4, 2016 Category: Journals (General) Tags: Arch Med Sci Source Type: research