• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Reducing persistent coronavirus infection in bats may lower the frequency of viral spillover to humans
Coronaviruses have been responsible for the emergence of pathogenic human diseases in recent decades, especially the coronavirus disease of 2019 (COVID-19). Phylogenetic studies of RNA (ribonucleic acid) viruses suggest that most human coronaviruses originated in bats, which are suitable reservoir hosts for many zoonotic viruses because of their unique biological and physiological features. The generation of human pathogenic coronaviruses is a result of genetic adaptation in bats and/or intermediate hosts, leading to spillover events. Therefore, we propose that specifically reducing or disrupting persistent coronavirus inf...
Source: The Journal of Infection in Developing Countries - March 30, 2022 Category: Infectious Diseases Source Type: research

Small interfering RNAs targeting agrA and sarA attenuate pathogenesis of Staphylococcus aureus in Caenorhabditis elegans
Conclusions: siRNA targeted toagrA andsarA lowered mRNA transcription and pathogenicity ofS. aureus.
Source: The Journal of Infection in Developing Countries - December 31, 2021 Category: Infectious Diseases Source Type: research