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Knockdown of FLT4, Nup98, and Nup205 cellular genes effectively suppresses the reproduction of influenza virus strain A/WSN/1933 (H1N1) in vitro
CONCLUSION: We identified a number of genes such as FLT4, Nup98, and Nup205, the decrease in the expression of which can effectively suppress viral reproduction. The original siRNA sequences were also obtained. These results are important for the creation of therapeutic and prophylactic agents, whose action is based on the RNA interference mechanism.PMID:35339191 | DOI:10.2174/1871526522666220325121403
Source: Infectious Disorders Drug Targets - March 27, 2022 Category: Infectious Diseases Authors: Evgeny Pashkov Ekaterina Korchevaya Evgeny Faizuloev Artem Rtishchev Bogdan Cherepovich Elizaveta Bystritskaya Alexander Sidorov Alexander Poddubikov Anatoly Bykov Yuliya Dronina Oxana Svitich Vitaliy Zverev Source Type: research

Controlling HCV infection by targeting its translation initiation site in PBMCs using siRNA; In Vitro.
Abstract Hepatitis C virus infection and its complications are among the leading public health challenges, the emergence of drug-resistant variants is expected to be a major problem. A combinatorial small interfering RNA (siRNA) could be a novel triple therapy that could be suitable for genotype 4. HCV believed to be hepatotropic, but there is liable evidence about its replication in peripheral blood mononuclear cells (PBMC) of chronic HCV infected patients. These cells act as an extra-hepatic reservoir for viral recurrence and persistence, patients with HCV-RNA in PBMC showed a significantly lower response to the...
Source: Infectious Disorders Drug Targets - November 14, 2018 Category: Infectious Diseases Authors: Youssef SS, Elemeery MN, Eldein SS, Ghareeb DA Tags: Infect Disord Drug Targets Source Type: research