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c-SRC protein tyrosine kinase regulates early HIV-1 infection post-entry
Conclusions: Our results suggest c-SRC tyrosine kinase is a major regulator of HIV-1 infection, participating in multiple stages of infection post-entry: Reduced proviral integration with increased 2-LTR circles is reminiscent of integrase inhibitors used in combination antiretroviral therapy. Decreasing c-SRC expression and/or activity provides a new target for antiviral intervention and the potential for repurposing existing FDA-approved kinase inhibitors.
Source: AIDS - March 15, 2016 Category: Infectious Diseases Tags: Basic Science Source Type: research

Atorvastatin restricts HIV replication in CD4+ T cells by upregulation of p21
Conclusion: The results demonstrate a novel mechanism by which atorvastatin induced resistance of CD4+ T cells to HIV-1 infection via p21 upregulation and suggest that statins may hold particular promise for some HIV-infected individuals.
Source: AIDS - December 23, 2015 Category: Infectious Diseases Tags: Basic Science Source Type: research

Disulfiram reactivates latent HIV-1 expression through depletion of the phosphatase and tensin homolog
Conclusion: DSF reactivates latent HIV-1 expression via the Akt signaling pathway through depletion of PTEN.
Source: AIDS - January 14, 2013 Category: Infectious Diseases Tags: Fast Track Source Type: research

HIV-1 trans-activator protein dysregulates IFN-γ signaling and contributes to the suppression of autophagy induction
Conclusion: HIV-1 Tat suppressed the induction of autophagy-associated genes and inhibited the formation of autophagosomes. Perturbation of such cellular processes by HIV-1 would impair the effective containment of invading pathogens, thereby providing a favorable environment for opportunistic microbes in HIV-infected individuals.
Source: AIDS - January 2, 2011 Category: Infectious Diseases Tags: Basic Science Source Type: research