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Pax6 affects Ras-Raf-ERK1/2 in mouse aging brain
Biogerontology. 2023 Jul 12. doi: 10.1007/s10522-023-10044-z. Online ahead of print.ABSTRACTPax6, a transcription factor and multifunctional protein, changes during aging. It also interacts with regulator proteins involved in cell metabolism and survival signalling pathways including Ras-GAP. Many forms of Ras, Raf and ERK1/2 are known but information on their region-specific expression patterns are unavailable from brain during aging. Therefore, it has been intended to evaluate expressions of Pax6 and forms of Ras, Raf, ERK1/2 in hippocampus, caudate nucleus, amygdale, cerebral cortex, cerebellum and olfactory lobe. Assoc...
Source: Biogerontology - July 12, 2023 Category: Geriatrics Authors: Khushboo Srivastava Rajnikant Mishra Source Type: research

SARS-COV-2 spike protein promotes RPE cell senescence via the ROS/P53/P21 pathway
In conclusions, the S-protein of SARS-Cov-2 induces cellular senescence of ARPE-19 cells in vitro and the expression of senescence-associated cytokines in zebrafish retina in vivo likely by activating ER stress, ROS, and NF-κb. These results may uncover a potential association between SARS-cov-2 infection and development of AMD.PMID:36738354 | PMC:PMC9898700 | DOI:10.1007/s10522-023-10019-0
Source: Biogerontology - February 4, 2023 Category: Geriatrics Authors: Yuhang Zhang Xuyan Peng Mengjiao Xue Jingjing Liu Guohui Shang Mingjun Jiang Dandan Chen Baixue Liu Yuxuan Wang Xiaolin Jia Jianqing Xu Fengyan Zhang Yanzhong Hu Source Type: research

17 β-estradiol inhibits H2O2-induced senescence in HUVEC cells through upregulating SIRT3 expression and promoting autophagy.
In this study, we examined the roles of SIRT3 in 17β-E2-induced autophagy and 17β-E2-mediated inhibition of hydrogen peroxide (H2O2)-induced senescence in Human umbilical vein endothelial cells (HUVEC). Cellular senescence was measured by immunoblot analysis with antibodies against phosphorylated Rb and senescence-associated β-galactosidase staining. Immunoblot analysis with antibodies against LC3 and p62 was performed to determine autophagy flux. Our findings show that 17β-E2 activates SIRT3 promoter and upregulates SIRT3 gene expression in HUVEC cells. siRNA-mediated silencing of SIRT3 gene expression inhibits 17β-E...
Source: Biogerontology - March 13, 2020 Category: Geriatrics Authors: Xiang X, Huang J, Song S, Wang Y, Zeng Y, Wu S, Ruan Y Tags: Biogerontology Source Type: research