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Insulin-Like Growth Factor I Prevents Cellular Aging via Activation of Mitophagy.
Authors: Hou X, Li Z, Higashi Y, Delafontaine P, Sukhanov S Abstract Mitochondrial dysfunction is a hallmark of cellular aging. Mitophagy is a critical mitochondrial quality control mechanism that removes dysfunctional mitochondria and contributes to cell survival. Insulin-like growth factor 1 (IGF-1) promotes survival of smooth muscle cells (SMCs), but its potential effect on cellular aging is unknown yet. We found that IGF-1 decreased cell senescence, prevented DNA telomere shortening, increased mitochondrial membrane potential, activated cytochrome C oxidase, and reduced mitochondrial DNA damage in long-term cul...
Source: Journal of Aging Research - August 19, 2020 Category: Geriatrics Tags: J Aging Res Source Type: research