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Specialty: Geriatrics
Condition: Parkinson's Disease
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Nothobranchius fish: an untapped resource for studying aging-related neurodegeneration.
Authors: Genade T
Abstract
New models in which aging-related neurodegeneration more closely resembling the combination of pathologies that develop in aging humans are needed. The fish Nothobranchius, which naturally develops such pathologies over the course of its short lifespan, is one such model. This review compares the lifespans and pathologies of different Nothobranchius strains to those of current vertebrate models of aging. Furthermore, existing data pertaining to neurodegeneration in these fish is discussed in the context of their reported neuropathologies, along with open questions related to mammalian chr...
Source: Current Aging Science - February 5, 2021 Category: Geriatrics Tags: Curr Aging Sci Source Type: research
