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Targeting of DNA Damage Signaling Pathway Induced Senescence and Reduced Migration of Cancer cells
The heat shock 70 family protein, mortalin, has pancytoplasmic distribution pattern in normal and perinuclear in cancer human cells. Cancer cells when induced to senesce by either chemicals or stress showed shift in mortalin staining pattern from perinuclear to pancytoplasmic type. Using such shift in mortalin staining as a reporter, we screened human shRNA library and identified nine senescence-inducing siRNA candidates. An independent Comparative Genomic Hybridization analysis of 35 breast cancer cell lines revealed that five (NBS1, BRCA1, TIN2, MRE11A, and KPNA2) of the nine genes located on chromosome regions identifie...
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - May 9, 2015 Category: Geriatrics Authors: Gao, R., Singh, R., Kaul, Z., Kaul, S. C., Wadhwa, R. Tags: Original Article Source Type: research