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Inflammatory Cytokine Interleukin-6 (IL-6) Promotes the Proangiogenic Ability of Adipose Stem Cells from Obese Subjects < em > via < /em > the IL-6 Signaling Pathway
CONCLUSION: The finding suggests that inflammatory cytokine interleukin-6 (IL-6) promotes the proangiogenic ability of obADSCs via the IL-6 signaling pathway.PMID:36883256 | DOI:10.2174/1574888X17666220429103935
Source: Current Stem Cell Research and Therapy - March 8, 2023 Category: Stem Cells Authors: Yuanyuan Zhang Pengju Lv Yalong Li Yonghui Zhang Chaofei Cheng Hongbo Hao Han Yue Source Type: research

YBX1 promotes MSC osteogenic differentiation by activating the PI3K/AKT pathway
CONCLUSION: Our study provides a new target and theoretical basis for the treatment of bone diseases.PMID:35929633 | DOI:10.2174/1574888X17666220805143833
Source: Current Stem Cell Research and Therapy - August 5, 2022 Category: Stem Cells Authors: Jiayu Chen Zhanliang Liu Huicheng Zhang Yongqian Yang Huangxiang Zeng Rongwei Zhong Shangdao Lai Hongxing Liao Source Type: research

Nanocarrier mediated siRNA delivery targeting stem cell differentiation.
Abstract Stem cell based regenerative medicine holds exceptional therapeutic potential and hence the development of efficient techniques to enhance control over the rate of differentiation has been the focus of active research. One of the strategies to achieve this involves delivering siRNA into stem cells and exploiting the RNA interference (RNAi) mechanism. Transport of siRNA across the cell membrane is a challenge due to its anionic property, especially in primary human cells and stem cells. Moreover, naked siRNA incites immune responses, may cause off-target effects, exhibits low stability and is easily degrad...
Source: Current Stem Cell Research and Therapy - November 30, 2019 Category: Stem Cells Authors: Fernandes F, Kotharkar P, Chakravorty A, Kowshik M, Talukdar I Tags: Curr Stem Cell Res Ther Source Type: research