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Canonical Notch signaling is required for bone morphogenetic protein ‐mediated human osteoblast differentiation
Bone morphogenetic protein (BMP) stimulation of bone ‐marrow‐derived human mesenchymal progenitor cells (hMSCs) increases Notch proteins via increased Notch ligand Jagged1 expression. Canonical Notch signaling is required for BMP‐induced ALPL expression and osteoblastic commitment of hMSCs. Both BMP‐induced osteoblastogenesis and Notch‐induc ed osteoblastogenesis require Runx2. AbstractOsteoblast differentiation of bone ‐marrow‐derived human mesenchymal stem cells (hMSC) can be induced by stimulation with canonical Notch ligand, Jagged1, or bone morphogenetic proteins (BMPs). However, it remains elusive how t...
Source: Stem Cells - June 23, 2020 Category: Stem Cells Authors: Yadav Wagley, Alessandra Chesi, Parker K. Acevedo, Sumei Lu, Andrew D. Wells, Matthew E. Johnson, Struan F. A. Grant, Kurt D. Hankenson Tags: Tissue ‐Specific Stem Cells Source Type: research

Canonical Notch Signaling is Required for Bone Morphogenetic Protein ‐mediated Human Osteoblast Differentiation
BMP stimulation of bone ‐marrow derived human mesenchymal progenitor cells (hMSCs) increases Notch proteins via increased Notch ligand Jagged1 expression. Canonical Notch signaling is required for BMPinduced ALPL expression and osteoblastic commitment of hMSCs. Both BMP‐induced osteoblastogenesis and Notch‐induced os teoblastogenesis require Runx2. AbstractOsteoblast differentiation of bone ‐marrow derived human mesenchymal stem cells (hMSC) can be induced by stimulation with either canonical Notch ligand, Jagged1, or bone morphogenetic proteins (BMP). However, it remains elusive how these two pathways lead to the ...
Source: Stem Cells - June 13, 2020 Category: Stem Cells Authors: Yadav Wagley, Alessandra Chesi, Parker K. Acevedo, Sumei Lu, Andrew D. Wells, Matthew E. Johnson, Struan F. A. Grant, Kurt D. Hankenson Tags: Tissue ‐Specific Stem Cells Source Type: research