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ASAP Nanoemulsion-Assisted siRNA Delivery to Modulate the Nervous Tumor Microenvironment in the Treatment of Pancreatic Cancer
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.1c21997
Source: ACS Applied Materials and Interfaces - February 21, 2022 Category: Materials Science Authors: Ling Ding, Siyuan Tang, Ao Yu, Anlin Wang, Weimin Tang, Huizhen Jia, and David Oupicky ́ Source Type: research

Facile one-step synthesis of NIR-Responsive siRNA-Inorganic hybrid nanoplatform for imaging-guided photothermal and gene synergistic therapy
Biomaterials. 2022 Jan 31;282:121404. doi: 10.1016/j.biomaterials.2022.121404. Online ahead of print.ABSTRACTDiagnosis-guided synergistic treatment based on innovative nanomaterials is of great significance for the development of anti-cancer therapies. However, the low delivery efficiency of therapeutic gene and the inability to trigger release on demand are still major obstacles impeding its wide application. Herein, we report an ultra-fast one-step method within 2 min to prepare a smart carrier, liposome-coated Prussian blue @ gold nano-flower, which is named LPAR after linking with tumor-targeting peptide. The versatile...
Source: Biomaterials - February 8, 2022 Category: Materials Science Authors: Xiuna Jia Mengmeng Lv Yunwei Fei Qing Dong Hao Wang Qiong Liu Dan Li Jin Wang Erkang Wang Source Type: research

Exosomes derived from immunogenically dying tumor cells as a versatile tool for vaccination against pancreatic cancer
Biomaterials. 2021 Dec 2;280:121306. doi: 10.1016/j.biomaterials.2021.121306. Online ahead of print.ABSTRACTDespite tremendous progress achieved in immunotherapy, many critical challenges in treating pancreatic ductal adenocarcinoma (PDAC) persist. Considering the poor vascularization of PDAC, after intramuscular administration exosomes can targeted deliver "cargos" to pancreatic tumors and bypass obstructions of the intrinsic overexpressed stroma through lymphatics. Herein, we propose a strategy to derive exosomes from immunogenically dying tumor cells and exploit their properties for several purposes, including antigen p...
Source: Biomaterials - December 24, 2021 Category: Materials Science Authors: Wenxi Zhou Xinli Chen Yu Zhou Si Shi Chen Liang Xianjun Yu Hongyi Chen Qin Guo Yiwen Zhang Peixin Liu Chao Li Yongchao Chu Yifan Luo Yu Wang Zheng Zhou Zhenhao Zhao Qinjun Chen Tao Sun Chen Jiang Source Type: research

Corrigendum to "Co-delivery of HIF1 α siRNA and gemcitabine via biocompatible lipid-polymer hybrid nanoparticles for effective treatment of pancreatic cancer" Biomaterials 46 (2015) 13-25
Biomaterials. 2021 Dec 7;280:121296. doi: 10.1016/j.biomaterials.2021.121296. Online ahead of print.NO ABSTRACTPMID:34890971 | DOI:10.1016/j.biomaterials.2021.121296
Source: Biomaterials - December 10, 2021 Category: Materials Science Authors: Xiao Zhao Feng Li Yiye Li Hai Wang He Ren Jing Chen Guangjun Nie Jihui Hao Source Type: research

Reduction-responsive RNAi nanoplatform to reprogram tumor lipid metabolism and repolarize macrophage for combination pancreatic cancer therapy
Biomaterials. 2021 Nov 19:121264. doi: 10.1016/j.biomaterials.2021.121264. Online ahead of print.ABSTRACTPancreatic cancer (PAC) is one of the most lethal malignant neoplasms with poor prognosis and high mortality. Emerging evidence has revealed that abnormal tumor lipid metabolism and tumor-associated macrophages (TAMs) significantly contribute to PAC development and progression. Therefore, concurrently reprogramming tumor lipid metabolism and regulating TAMs function could be a promising strategy for effective PAC therapy. Herein, we identified an important enzyme catabolizing lipids (monoacylglycerol lipase, MGLL) and a...
Source: Biomaterials - November 26, 2021 Category: Materials Science Authors: Shuwen Cao Phei Er Saw Qian Shen Rong Li Yun Liu Xiaoding Xu Source Type: research

Pancreatic stellate cells derived from human pancreatic cancer demonstrate aberrant SPARC-dependent ECM remodeling in 3D engineered fibrotic tissue of clinically relevant thickness.
Abstract Desmoplasia is a hallmark of pancreatic cancer and consists of fibrotic cells and secreted extracellular matrix (ECM) components. Various in vitro three-dimensional (3D) models of desmoplasia have been reported, but little is known about the relevant thickness of the engineered fibrotic tissue. We thus measured the thickness of fibrotic tissue in human pancreatic cancer, as defined by the distance from the blood vessel wall to tumor cells. We then generated a 3D fibrosis model with a thickness reaching the clinically observed range using pancreatic stellate cells (PSCs), the main cellular constituent of p...
Source: Biomaterials - November 17, 2018 Category: Materials Science Authors: Tanaka HY, Kitahara K, Sasaki N, Nakao N, Sato K, Narita H, Shimoda H, Matsusaki M, Nishihara H, Masamune A, Kano MR Tags: Biomaterials Source Type: research

Precision design of nanomedicines to restore gemcitabine chemosensitivity for personalized pancreatic ductal adenocarcinoma treatment.
Abstract Low chemosensitivity considerably restricts the therapeutic efficacy of gemcitabine (GEM) in pancreatic cancer treatment. Using immunohistochemical evaluation, we investigated that decreased expression of human equilibrative nucleoside transporter-1 (hENT1, which is the major GEM transporter across cell membranes) and increased expression of ribonucleotide reductase subunit 2 (RRM2, which decreases the cytotoxicity of GEM) was associated with low GEM chemosensitivity. To solve these problems, we employed a nanomedicine-based formulation of cationic liposomes for co-delivery of GEM along with siRNA targeti...
Source: Biomaterials - December 20, 2017 Category: Materials Science Authors: Zhao X, Wang X, Sun W, Cheng K, Qin H, Han X, Lin Y, Wang Y, Lang J, Zhao R, Zheng X, Zhao Y, Shi J, Hao J, Miao QR, Nie G, Ren H Tags: Biomaterials Source Type: research

Co-delivery of HIF1α siRNA and gemcitabine via biocompatible lipid-polymer hybrid nanoparticles for effective treatment of pancreatic cancer.
Abstract Hypoxia-inducible factor 1α (HIF1α) has emerged as a promising new target for pancreatic cancer treatment over the past decade. High expression of HIF-1α increases the drug resistance of the current first line chemotherapeutic drug, gemcitabine (Gem). Here we employed biocompatible lipid-polymer hybrid nanoparticles to co-deliver HIF1α siRNA (si-HIF1α) and Gem for pancreatic cancer treatment in subcutaneous and orthotopic tumor models. The cationic ε-polylysine co-polymer (ENPs) can effectively absorb negatively charged si-HIF1α on the surface and encapsulate Gem to the hydrophilic core. Further co...
Source: Biomaterials - February 15, 2015 Category: Materials Science Authors: Zhao X, Li F, Li Y, Wang H, Ren H, Chen J, Nie G, Hao J Tags: Biomaterials Source Type: research

Tumor targeting RGD conjugated bio-reducible polymer for VEGF siRNA expressing plasmid delivery.
Abstract Targeted delivery of therapeutic genes to the tumor site is critical for successful and safe cancer gene therapy. The arginine grafted bio-reducible poly (cystamine bisacrylamide-diaminohexane, CBA-DAH) polymer (ABP) conjugated poly (amido amine) (PAMAM), PAM-ABP (PA) was designed previously as an efficient gene delivery carrier. To achieve high efficacy in cancer selective delivery, we developed the tumor targeting bio-reducible polymer, PA-PEG1k-RGD, by conjugating cyclic RGDfC (RGD) peptides, which bind αvβ3/5 integrins, to the PAM-ABP using polyethylene glycol (PEG, 1 kDa) as a spacer. Physical cha...
Source: Biomaterials - May 31, 2014 Category: Materials Science Authors: Kim HA, Nam K, Kim SW Tags: Biomaterials Source Type: research