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Specialty: Materials Science
Cancer: Cancer
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Total 119 results found since Jan 2013.
Synchronous targeted delivery of TGF- β siRNA to stromal and tumor cells elicits robust antitumor immunity against triple-negative breast cancer by comprehensively remodeling the tumor microenvironment
Biomaterials. 2023 Jul 25;301:122253. doi: 10.1016/j.biomaterials.2023.122253. Online ahead of print.ABSTRACTThe poor permeability of therapeutic drugs, limited T-cell infiltration, and strong immunosuppressive tumor microenvironment of triple-negative breast cancer (TNBC) acts as a prominent barrier to the delivery of drugs and immunotherapy including programmed cell death ligand-1 antibody (anti-PD-L1). Transforming growth factor (TGF)-β, an important cytokine produced by cancer-associated fibroblasts (CAFs) and tumor cells contributes to the pathological vasculature, dense tumor stroma and strong immunosuppressive tumo...
Source: Biomaterials - August 3, 2023 Category: Materials Science Authors: Mengmeng Yang Chao Qin Linlin Tao Gang Cheng Jingjing Li Fangnan Lv Nan Yang Zuhang Xing Xinyu Chu Xiaopeng Han Meirong Huo Lifang Yin Source Type: research
ASAP Inhalable siRNA Nanoparticles for Enhanced Tumor-Targeting Treatment of < italic toggle="yes" > KRAS < /italic > -Mutant Non-Small-Cell Lung Cancer
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.3c05007
Source: ACS Applied Materials and Interfaces - June 24, 2023 Category: Materials Science Authors: Guolin Zhao, William Ho, Jinxian Chu, Xiaojian Xiong, Bin Hu, Kofi Oti Boakye-Yiadom, Xiaoyang Xu, and Xue-Qing Zhang Source Type: research
ASAP β‑Glucan-Mediated Oral Codelivery of 5FU and Bcl2 siRNA Attenuates Stomach Cancer
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.3c03528
Source: ACS Applied Materials and Interfaces - June 23, 2023 Category: Materials Science Authors: Humayra Afrin, Stephanie Vargas Esquivel, Raj Kumar, Md Ikhtiar Zahid, Ikhtiar Zahid, Beu Oporeza, Md Fashiar Rahman, Thomas Boland, and Md Nurunnabi Source Type: research
Evaluation of a DoE based approach for comprehensive modelling of the effect of lipid nanoparticle composition on nucleic acid delivery
Biomaterials. 2023 May 15;299:122158. doi: 10.1016/j.biomaterials.2023.122158. Online ahead of print.ABSTRACTTherapeutic nucleic acids (TNAs) comprise an alternative to conventional drugs for cancer therapy. Recently, stable nucleic acid lipid particles (SNALPs) have been explored to deliver TNA efficiently and safely both in vitro and in vivo. Small interfering RNA (siRNA) and messenger RNA (mRNA) based drugs have been suggested for a wide range of pathologies, and their respective lipid nanoparticle (LNP) formulations have been optimised using a Design of Experiments (DoE) approach. However, it is uncertain as to whether...
Source: Biomaterials - May 27, 2023 Category: Materials Science Authors: Yue Qin Adam A Walters Nadia Rouatbi Julie Tzu-Wen Wang Hend Mohamed Abdel-Bar Khuloud T Al-Jamal Source Type: research
Corrigendum to "Redox-responsive polyprodrug nanoparticles for targeted siRNA delivery and synergistic liver cancer therapy" Biomater. 234 (2020) 119760
Biomaterials. 2022 Dec 14;293:121951. doi: 10.1016/j.biomaterials.2022.121951. Online ahead of print.NO ABSTRACTPMID:36525705 | DOI:10.1016/j.biomaterials.2022.121951
Source: Biomaterials - December 16, 2022 Category: Materials Science Authors: Senlin Li Phei Er Saw Chunhao Lin Yan Nie Wei Tao Omid C Farokhzad Lei Zhang Xiaoding Xu Source Type: research
Self-amplified ROS production from fatty acid oxidation enhanced tumor immunotherapy by atorvastatin/PD-L1 siRNA lipopeptide nanoplexes
Biomaterials. 2022 Nov 3;291:121902. doi: 10.1016/j.biomaterials.2022.121902. Online ahead of print.ABSTRACTDespite the important role of reactive oxygen species (ROS) in battling cancer, ROS production with current approaches has been severely limited by the deficiency of oxy-substrates in tumor microenvironment. Herein, an atorvastatin (Ato)-catalytic self-amplified approach was utilized for sustainable ROS production and enhancing anti-tumor efficacy of PD-L1 silencing. A C18-pArg8-ss-pHis10 lipopeptide based self-assembled nanoplexes was developed to co-encapsulate AMP-activated protein kinase (AMPK) activator of Ato a...
Source: Biomaterials - November 13, 2022 Category: Materials Science Authors: Yan Gao Zilin Song Li Jia Yi Tang Chengcheng Wang Xiuli Zhao Haiyang Hu Dawei Chen Mingxi Qiao Source Type: research
Precision medicine-guided co-delivery of ASPN siRNA and oxaliplatin by nanoparticles to overcome chemoresistance of colorectal cancer
This study uncovered the critical role of ASPN in causing OXA resistance in CRC patients and suggests a promising nanoformulation that may be more effective than current standard-of-care medications.PMID:36228517 | DOI:10.1016/j.biomaterials.2022.121827
Source: Biomaterials - October 13, 2022 Category: Materials Science Authors: Cheng-Zhi Huang Yue Zhou Qi-Song Tong Qi-Jia Duan Qing Zhang Jin-Zhi Du Xue-Qing Yao Source Type: research
Ru(II)-modified TiO < sub > 2 < /sub > nanoparticles for hypoxia-adaptive photo-immunotherapy of oral squamous cell carcinoma
Biomaterials. 2022 Aug 24;289:121757. doi: 10.1016/j.biomaterials.2022.121757. Online ahead of print.ABSTRACTThe alternations in the hypoxic and immune microenvironment are closely related to the therapeutic effect and prognosis of oral squamous cell carcinoma (OSCC). Herein, a new nanocomposite, TiO2@Ru@siRNA is constructed from a ruthenium-based photosensitizer (Ru) modified-TiO2 nanoparticles (NPs) loaded with siRNA of hypoxia-inducible factor-1α (HIF-1α). Under visible light irradiation, TiO2@Ru@siRNA can elicit both Type I and Type II photodynamic effects, which causes lysosomal damage, HIF-1α gene silencing, and O...
Source: Biomaterials - September 4, 2022 Category: Materials Science Authors: Jia-Ying Zhou Wen-Jin Wang Chen-Yu Zhang Yu-Yi Ling Xiao-Jing Hong Qiao Su Wu-Guo Li Zong-Wan Mao Bin Cheng Cai-Ping Tan Tong Wu Source Type: research
ASAP Self-Assembly of a Multifunction DNA Tetrahedron for Effective Delivery of Aptamer PL1 and < italic toggle="yes" > Pcsk9 < /italic > siRNA Potentiate Immune Checkpoint Therapy for Colorectal Cancer
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.2c06001
Source: ACS Applied Materials and Interfaces - July 11, 2022 Category: Materials Science Authors: Wenjing Guo, Huabin Gao, Hui Li, Songhan Ge, Fenfen Zhang, Liyuan Wang, Huijuan Shi, and Anjia Han Source Type: research
