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New and future therapies: Changes in the therapeutic armamentarium for SLE
Best Pract Res Clin Rheumatol. 2023 Aug 24:101865. doi: 10.1016/j.berh.2023.101865. Online ahead of print.ABSTRACTFollowing better understanding of molecular pathways involved in the pathogenesis of Systemic lupus erythematosus (SLE), pharmaceutical companies have been investigating new targeted drugs for SLE. The purpose of this scoping review is to provide an updated view of the most promising targeted therapies currently in clinical development or recently approved for SLE treatment as well as of the most promising potential future therapeutic strategies in SLE. In the past several years, two new drugs have been develop...
Source: Cell Research - August 26, 2023 Category: Cytology Authors: Anca Askanase Leila Khalili Wei Tang Philippe Mertz Marc Scherlinger Eden Sebbag Fran çois Chasset Renaud Felten Laurent Arnaud Source Type: research

Novel siRNA therapeutics demonstrate multi-variant efficacy against SARS-CoV-2
Antiviral Res. 2023 Jul 19:105677. doi: 10.1016/j.antiviral.2023.105677. Online ahead of print.ABSTRACTSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a respiratory virus that causes COVID-19 disease, with an estimated global mortality of approximately 2%. While global response strategies, which are predominantly reliant on regular vaccinations, have shifted from zero COVID to living with COVID, there is a distinct lack of broad-spectrum direct acting antiviral therapies that maintain efficacy across evolving SARS-CoV-2 variants of concern. This is of most concern for immunocompromised and immunosuppressed ...
Source: Cell Research - July 21, 2023 Category: Cytology Authors: Ellen Bowden-Reid Scott Ledger Yuan Zhang Francesca Di Giallonardo Anupriya Aggarwal Alberto Ospina Stella Anouschka Akerman Vanessa Milogiannakis Gregory Walker William Rawlinson Stuart Turville Anthony D Kelleher Chantelle Ahlenstiel Source Type: research

Directing the Way-Receptor and Chemical Targeting Strategies for Nucleic Acid Delivery
Pharm Res. 2022 Sep 15. doi: 10.1007/s11095-022-03385-w. Online ahead of print.ABSTRACTNucleic acid therapeutics have shown great potential for the treatment of numerous diseases, such as genetic disorders, cancer and infections. Moreover, they have been successfully used as vaccines during the COVID-19 pandemic. In order to unfold full therapeutical potential, these nano agents have to overcome several barriers. Therefore, directed transport to specific tissues and cell types remains a central challenge to receive carrier systems with enhanced efficiency and desired biodistribution profiles. Active targeting strategies in...
Source: Cell Research - September 15, 2022 Category: Cytology Authors: Ricarda Carolin Steffens Ernst Wagner Source Type: research

Dual Blockade of PD-1 and LAG3 Immune Checkpoints Increases Dendritic Cell Vaccine Mediated T Cell Responses in Breast Cancer Model
CONCLUSION: These findings strongly suggest that TMC-DS-L NPs loaded with siRNA could act as a novel tool in inhibiting the expression of immune checkpoints in the tumor microenvironment. Also, combination therapy based on inhibition of PD-1 and LAG3 in combination with DC vaccine is an effective method in treating cancer that needs to be further studied.PMID:35715669 | DOI:10.1007/s11095-022-03297-9
Source: Cell Research - June 17, 2022 Category: Cytology Authors: Asal Barshidi Vahid Karpisheh Fatemeh Karimian Noukabadi Fariba Karoon Kiani Mohammad Mohammadi Negin Afsharimanesh Farbod Ebrahimi Seyed Hossein Kiaie Jamshid Gholizadeh Navashenaq Mohammad Hojjat-Farsangi Naime Majidi Zolbanin Ata Mahmoodpoor Hadi Hassa Source Type: research

Combination Cancer Immunotherapy with Dendritic Cell Vaccine and Nanoparticles Loaded with Interleukin-15 and Anti-beta-catenin siRNA Significantly Inhibits Cancer Growth and Induces Anti-Tumor Immune Response
CONCLUSIONS: These findings suggest that the use of new nanocarriers such as SPION-C-CMD-FA could be an effective way to use as a novel combination therapy consisting of β-catenin siRNA, IL-15, and DC vaccine to treat cancer.PMID:35166995 | DOI:10.1007/s11095-022-03169-2
Source: Cell Research - February 15, 2022 Category: Cytology Authors: Armin Mahmoud Salehi Kheshti Farnaz Hajizadeh Asal Barshidi Bentolhoda Rashidi Farbod Ebrahimi Simin Bahmanpour Vahid Karpisheh Fatemeh Karimian Noukabadi Fariba Karoon Kiani Hadi Hassannia Fatemeh Atyabi Seyed Hossein Kiaie Fatah Kashanchi Jamshid Gholiz Source Type: research

Developing Biodegradable Lipid Nanoparticles for Intracellular mRNA Delivery and Genome Editing
Acc Chem Res. 2021 Oct 20. doi: 10.1021/acs.accounts.1c00500. Online ahead of print.ABSTRACTConspectusSince the U.S. Food and Drug Administration (FDA) granted emergency use authorization for two mRNA vaccines against SARS-CoV-2, mRNA-based technology has attracted broad attention from the scientific community to investors. When delivered intracellularly, mRNA has the ability to produce various therapeutic proteins, enabling the treatment of a variety of illnesses, including but not limited to infectious diseases, cancers, and genetic diseases. Accordingly, mRNA holds significant therapeutic potential and provides a promis...
Source: Cell Research - October 20, 2021 Category: Cytology Authors: Min Qiu Yamin Li Hanan Bloomer Qiaobing Xu Source Type: research

Autophagy induction by the pathogen receptor NECTIN4 and sustained autophagy contribute to peste des petits ruminants virus infectivity.
Abstract Macroautophagy/autophagy is an essential cellular response in the fight against intracellular pathogens. Although some viruses can escape from or utilize autophagy to ensure their own replication, the responses of autophagy pathways to viral invasion remain poorly documented. Here, we show that peste des petits ruminants virus (PPRV) infection induces successive autophagic signalling in host cells via distinct and uncoupled molecular pathways. Immediately upon invasion, PPRV induced a first transient wave of autophagy via a mechanism involving the cellular pathogen receptor NECTIN4 and an AKT-MTOR-depende...
Source: Autophagy - July 17, 2019 Category: Cytology Authors: Yang B, Xue Q, Guo J, Wang X, Zhang Y, Guo K, Li W, Chen S, Xue T, Qi X, Wang J Tags: Autophagy Source Type: research

Autocrine CCL19 blocks dendritic cell migration toward weak gradients of CCL21
Conclusions. Our results demonstrate that autocrine CCL19 negatively affects DC migratory potential toward CCL21, the potency difference between CCL19 and CCL21 being the underlying cause. CCL19 secretion level of in vitro matured DCs is an important indicator of DC vaccine homing potential.
Source: Cytotherapy - July 14, 2016 Category: Cytology Source Type: research