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IFNγ-induced JAK/STAT-, but not NF-κB-, signaling pathway is insensitive to glucocorticoid in airway epithelial cells.
Abstract Although the majority of asthmatics are well controlled by inhaled glucocorticoids (GCs), severe asthmatics are poorly responsive to GCs. This latter group is responsible for a disproportionate share of healthcare costs associated with asthma. Recent studies in immune cells have incriminated interferon gamma (IFNγ) as a possible trigger of GC insensitivity in severe asthma; however, little is known about the role of IFNγ in modulating GC effects in other clinically relevant non-immune cells, such as airway epithelial cells. We hypothesized that IFNγ-induced JAK/STAT-associated signaling pathways in air...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - June 19, 2015 Category: Cytology Authors: O'Connell D, Bouazza B, Kokalari B, Amrani Y, Khatib A, Ganther JD, Tliba O Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research