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Specialty: Cytology
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Total 1 results found since Jan 2013.
Impaired ALDH2 activity decreases the mitochondrial respiration in H9C2 cardiomyocytes.
Abstract
Reactive oxygen species (ROS)-mediated reactive aldehydes induce cellular stress. In cardiovascular diseases such as ischemia-reperfusion injury, lipid-peroxidation derived reactive aldehydes such as 4-hydroxy-2-nonenal (4HNE) are known to contribute to the pathogenesis. 4HNE is involved in ROS formation, abnormal calcium handling and more importantly defective mitochondrial respiration. Aldehyde dehydrogenase (ALDH) superfamily contains NAD(P)(+)-dependent isozymes which can detoxify endogenous and exogenous aldehydes into non-toxic carboxylic acids. Therefore we hypothesize that 4HNE afflicts mitochondr...
Source: Cellular Signalling - November 11, 2015 Category: Cytology Authors: Mali VR, Deshpande M, Pan G, Thandavarayan RA, Palaniyandi SS Tags: Cell Signal Source Type: research
