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Intestinal UDP-glucuronosyltransferase as a potential target for the treatment and prevention of lymphatic filariasis
by Alexander F. Flynn, M. Gordon Joyce, Rebekah T. Taylor, Sasisekhar Bennuru, Alyssa R. Lindrose, Spencer L. Sterling, C. Paul Morris, Thomas B. Nutman, Edward Mitre Lymphatic filariasis (LF), a morbid disease caused by the tissue-invasive nematodesWuchereria bancrofti,Brugia malayi, andBrugia timori, affects millions of people worldwide. Global eradication efforts have significantly reduced worldwide prevalence, but complete elimination has been hampered by limitations of current anti-filarial drugs and the lack of a vaccine. The goal of this study was to evaluateB.malayi intestinal UDP-glucuronosyltransferase (Bm-UGT) ...
Source: PLoS Neglected Tropical Diseases - September 11, 2019 Category: Tropical Medicine Authors: Alexander F. Flynn Source Type: research