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Flagellin-independent effects of a Toll-like receptor 5 polymorphism in the inflammatory response to < i > Burkholderia pseudomallei < /i >
Conclusions/SignificanceThe effects of the common nonsenseTLR5:c.1174C>T polymorphism on the host inflammatory response toB.pseudomallei may not be restricted to flagellin-driven pathways. Moreover, TLR5 may modulate TLR4-dependent cytokine production. While these results may have broader implications for the role of TLR5 in the innate immune response in melioidosis and other conditions, further studies of the mechanisms underlying these observations are required.
Source: PLoS Neglected Tropical Diseases - May 7, 2019 Category: Tropical Medicine Authors: Amy K. Dickey Source Type: research