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< i > Trichinella spiralis < /i > : Knockdown of gamma interferon inducible lysosomal thiol reductase (GILT) results in the reduction of worm burden
by Hong Fei, Muhammad Ali-ul-Husnain Naqvi, Sana Zahra Naqvi, Lixin Xu, Xiaokai Song, Xiangrui Li, Ruofeng YanTrichinella spiralis is mammalian skeletal muscles parasite which may cause trichinellosis in animals and humans. Gamma interferon inducible lysosomal thiol reductase (GILT) is a widespread superfamily which plays key role in processing and presentation of MHC class II restricted antigen by catalyzing disulfide bond reduction. There are no reports about GILT inT.spiralis. In present study, GILT fromT.spiralis (Tsp-GILT) was cloned, analyzed by multiple-sequence alignment, and predicted by 3D structure model. Recomb...
Source: PLoS Neglected Tropical Diseases - November 30, 2021 Category: Tropical Medicine Authors: Hong Fei Source Type: research