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In  vitro inhibitory analysis of consensus siRNAs against NS3 gene of hepatitis C virus 1a genotype
Conclusions siRNAs directed against NS3 gene significantly decreased mRNA and protein expression in stable cell clones. Viral replication was also vividly decreased in serum infected Huh-7 cells. Stable Huh-7 cells expressing NS3 gene is helpful to develop anti-hepatitis C drug screening assays. siRNA therapeutic potential along with other anti-HCV agents can be considered against hepatitis C.
Source: Asian Pacific Journal of Tropical Medicine - August 18, 2017 Category: Tropical Medicine Source Type: research

In vitro inhibitory analysis of consensus siRNAs against NS3 gene of hepatitis C virus 1a genotype
Conclusions siRNAs directed against NS3 gene significantly decreased mRNA and protein expression in stable cell clones. Viral replication was also vividly decreased in serum infected Huh-7 cells. Stable Huh-7 cells expressing NS3 gene is helpful to develop anti-hepatitis C drug screening assays. siRNA therapeutic potential along with other anti-HCV agents can be considered against hepatitis C.
Source: Asian Pacific Journal of Tropical Medicine - August 9, 2017 Category: Tropical Medicine Source Type: research

Effect of siRNA on Wisp-1 gene expression, proliferation, migration and adhesion of mouse hepatocellular carcinoma cells
Conclusions The inhibition of Wisp-1 expression can reduce the proliferation, migration and adhesion of mouse hepatocellular carcinoma cells, which is related to the AKT/glycogen synthase kinase-3β pathway. Wisp-1 gene may be the potential target to cure the hepatocellular carcinoma.
Source: Asian Pacific Journal of Tropical Medicine - October 4, 2015 Category: Tropical Medicine Source Type: research

Expression of HIP/PAP in hepatocellular carcinoma and effect of siRNA on migration and invasion in HCC cells
Conclusions HIP/APA is overexpressed in HCC and contributes to the migration and invasion of HCC cells.
Source: Asian Pacific Journal of Tropical Medicine - September 25, 2015 Category: Tropical Medicine Source Type: research

HSP90 and SIRT3 expression in hepatocellular carcinoma and their effect on invasive capability of human hepatocellular carcinoma cells
Conclusions Carcinoma HepG2 cell transfected high expression of HSP can promote the transformation of EMT, improve the expression of Vimentin, reduce the expression of E-cadherin, and inhibit apoptosis of cancer stem cells, which improve the invasive ability of cancer of the liver cells. While hsp-siRNA group presents opposite results. In summary, the expression of HSP is closely related to the occurrence, development and invasion of cancer of the liver tissue.
Source: Asian Pacific Journal of Tropical Medicine - May 11, 2015 Category: Tropical Medicine Source Type: research

Lentivirus vectors construction of SiRNA targeting interference GPC3 gene and its biological effects on liver cancer cell lines Huh-7
Conclusions The targeted GPC3 siRNA can effectively inhibit the expression of GPC3.
Source: Asian Pacific Journal of Tropical Medicine - October 12, 2014 Category: Tropical Medicine Source Type: research