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PKC-delta mediates mineralocorticoid receptor activation by angiotensin II to modulate smooth muscle cell function.
Abstract Angiotensin II (AngII) and the mineralocorticoid receptor(MR) ligand aldosterone, both contribute to cardiovascular disorders, including hypertension and adverse vascular remodeling.We previously demonstrated that AngII activates MR-mediated gene transcription in human vascular smooth muscle cells(SMC) yet the mechanism and the impact on SMC function are unknown.Using a MR responsive element-driven transcriptional reporter assay, we confirm that AngII induces MR transcriptional activity in multiple vascular SMC and endothelial cells, but not in Cos1 nor HEK293 cells.AngII activation of MR was blocked by t...
Source: Endocrinology - August 1, 2019 Category: Endocrinology Authors: Lu Q, Davel AP, McGraw AP, Rao SP, Newfell BG, Jaffe IZ Tags: Endocrinology Source Type: research

Antioxidant N-acetylcysteine protects pancreatic β-cells against aldosterone-induced oxidative stress and apoptosis in female db/db mice and insulin-producing MIN6 cells.
This study aimed to investigate whether oxidative stress is involved in and whether the antioxidant N-acetylcysteine (NAC) or the mineralocorticoid receptor (MR) antagonist spironolactone could prevent or delay β-cell damage in vivo and in vitro. As expected, 8 weeks after aldosterone treatment, 12-week-old female diabetic db/db mice exhibited impaired oral glucose tolerance, decreased β-cell mass, and heightened levels of oxidative stress marker (urinary 8-OHdG). NAC reversed these symptoms completely, whereas spironolactone treatment did so only partially. After exposure to aldosterone, the mouse pancreatic β-cell lin...
Source: Endocrinology - September 5, 2013 Category: Endocrinology Authors: Jin HM, Zhou DC, Gu HF, Qiao QY, Fu SK, Liu XL, Pan Y Tags: Endocrinology Source Type: research