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Infectious Disease: Outbreaks
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Total 2 results found since Jan 2013.
Targeting HMGB1 inhibits T-2 toxin-induced neurotoxicity via regulation of oxidative stress, neuroinflammation and neuronal apoptosis
Food Chem Toxicol. 2021 Mar 21:112134. doi: 10.1016/j.fct.2021.112134. Online ahead of print.ABSTRACTT-2 toxin, a food-derived mycotoxin, has been identified as a neurotoxin. Nonetheless, T-2 toxin-induced neuroinflammation has never been revealed. As an important therapeutic target for inflammatory diseases and cancers, the role of high mobility group B1 (HMGB1) in mycotoxin-mediated neurotoxicity remains a mystery. In current study, we found that PC12 cells were sensitive to trace amounts of T-2 toxin less than 12 ng/mL, distinguished by decreased cell viability and increased release of lactate dehydrogenase (LDH). Oxida...
Source: Food and Chemical Toxicology - March 25, 2021 Category: Food Science Authors: Xingyao Pei Haiyang Jiang Xinyu Liu Liuan Li Cun Li Xilong Xiao Daowen Li Shusheng Tang Source Type: research
