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Apoptotic cell death induced by Z-Ligustilidein human ovarian cancer cells and role of NRF2.
Abstract Z-Ligustilide is the most potent bioactive component of Angelica sinensis, which is widely used in Chinese traditional medicine. Z-Ligustilide selectively affected ovarian cancer cell survival in a dose dependent manner. Z-Ligustilide induced apoptotic cell death was determined by flow cytometry. We also demonstrated that apoptotic cell death was triggered by Z-Ligustilideinduced oxidative stress and mitochondria played an active role. Mitochondrial polarization was reduced by Z-Ligustilidewhereas mitochondrial superoxide formation was increased. NRF2 was induced by Z-Ligustilide in OVCAR-3 cells at epi...
Source: Food and Chemical Toxicology - September 20, 2018 Category: Food Science Authors: Lang F, Qu J, Yin H, Li L, Zhi Y, Liu Y, Fang Z, Hao E Tags: Food Chem Toxicol Source Type: research