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Stimulus-responsive hybrid nanoparticles based on multiple lipids for the co-delivery of doxorubicin and Sphk2-siRNA and breast cancer therapy
Food Chem Toxicol. 2022 Nov 28:113532. doi: 10.1016/j.fct.2022.113532. Online ahead of print.NO ABSTRACTPMID:36455683 | DOI:10.1016/j.fct.2022.113532
Source: Food and Chemical Toxicology - December 1, 2022 Category: Food Science Authors: Jinying Liang Shiqi Guo Mengxin Bai Mengying Huang Yupeng Qu Ying Zhao Yu Song Source Type: research

Fisetin inhibits cell migration via inducing HO-1 and reducing MMPs expression in breast cancer cell lines.
Abstract Metastasis is commonly seen in advanced stage of cancers, and matrix metalloproteinases (MMPs) are commonly up-regulated and have been identified as critical regulators. In this present study, a flavonoid, fisetin, which can be found in diverse foods, is investigated for its ability to inhibit cell motility, and the underlying mechanism is also studied in breast cancer cells (4T1 and JC cells). We have revealed that fisetin increased HO-1 mRNA and protein expressions. Besides, fisetin also elevated Nrf2 expression in nuclear fraction. By silencing Nrf2, fisetin-induced HO-1 expression was abrogated, sugge...
Source: Food and Chemical Toxicology - August 1, 2018 Category: Food Science Authors: Tsai CF, Chen JH, Chang CN, Lu DY, Chang PC, Wang SL, Yeh WL Tags: Food Chem Toxicol Source Type: research

α-Mangostin-induced apoptosis is mediated by estrogen receptor α in human breast cancer cells.
In this study, we evaluated the effects of α-mangostin on cell growth inhibition and induction of apoptosis in MCF-7 ERα-positive human breast cancer cells. Our results showed that α-mangostin inhibited MCF-7 cell proliferation whereas ERα-negative MDA-MB-231 cells were less sensitive to the agent. Additionally, α-mangostin effectively induced apoptosis as evidenced by the appearance of apoptotic nuclei observed with Hoechst 33258 staining and evaluation of sub-G1 DNA contents by flow cytometry. α-Mangostin also activated caspases-8, -9, and -7; increased the protein levels of Bax, p53, and cytosolic cytochrome c; an...
Source: Food and Chemical Toxicology - January 28, 2014 Category: Food Science Authors: Won YS, Lee JH, Kwon SJ, Kim JY, Park KH, Lee MK, Seo KI Tags: Food Chem Toxicol Source Type: research