• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Rubus idaeus L. Reverses Epithelial-to-Mesenchymal Transition and Suppresses Cell Invasion and Protease Activities by Targeting ERK1/2 and FAK Pathways in Human Lung Cancer Cells.
Abstract Epithelial to mesenchymal transition (EMT) has been considered essential for cancer metastasis, a multistep complicated process including local invasion, intravasation, extravasation, and proliferation at distant sites. Herein we provided molecular evidence associated with the antimetastatic effect of Rubus idaeus L. extracts (RIE) by showing a nearly complete inhibition on the invasion (p < 0.001) of highly metastatic A549 cells via reduced activities of matrix metalloproteinase-2 (MMP-2) and urokinasetype plasminogen activator (u-PA). We performed Western blot to find that RIE could induce up-regulat...
Source: Food and Chemical Toxicology - October 23, 2013 Category: Food Science Authors: Hsieh YS, Chu SC, Hsu LS, Chen KS, Lai MT, Yeh CH, Chen PN Tags: Food Chem Toxicol Source Type: research