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Viruses, Vol. 7, Pages 1474-1491: Chondroitin Sulfate N-acetylgalactosaminyltransferase-2 Contributes to the Replication of Infectious Bursal Disease Virus via Interaction with the Capsid Protein VP2
Infectious bursal disease virus (IBDV) is a birnavirus that causes a highly contagious immunosuppressive disease in young chickens. The capsid protein VP2 of IBDV plays multiple roles in its life cycle. To more comprehensively understand the functions of VP2 involved in the communication between virus and host, we used yeast two-hybrid screening to identify the cellular factors that interact with this protein. We found that chondroitin sulfate N-acetylgalactosaminyltransferase-2 (CSGalNAcT2), a typical type II transmembrane protein located in Golgi apparatus, could interact with VP2, and we confirmed this interaction by co...
Source: Viruses - March 23, 2015 Category: Virology Authors: Lizhou ZhangXiangang RenYuming ChenYulong GaoNian WangZhen LuLi GaoLiting QinYongqiang WangHonglei GaoKai LiLili JiangHongyu CuiChangjun LiuYanping ZhangXiaole QiXiaomei Wang Tags: Article Source Type: research

Annexin 2 is a host protein binding to classical swine fever virus E2 glycoprotein and promoting viral growth in PK-15 cells.
In conclusion, Anx2 is the novel host protein identified to interact with CSFV E2 and promote CSFV multiplication. These observations provide support for the potential use of Anx2 as a cellular target for the development of novel anti-CSFV therapies. PMID: 25701745 [PubMed - as supplied by publisher]
Source: Virus Research - February 18, 2015 Category: Virology Authors: Yang Z, Shi Z, Guo H, Qu H, Zhang Y, Tu C Tags: Virus Res Source Type: research

The mammalian orthoreovirus bicistronic M3 mRNA initiates translation using a 5' end-dependent, scanning mechanism that does not require interaction of 5'-3' untranslated regions.
Abstract Mammalian orthoreovirus mRNAs possess short 5' UTR, lack 3' poly(A) tails, and may lack 5' cap structures at late times post-infection. As such, the mechanisms by which these viral mRNAs recruit ribosomes remain completely unknown. Toward addressing this question, we used bicistronic MRV M3 mRNA to analyze the role of 5' and 3' UTRs during MRV protein synthesis. The 5' UTR was found to be dispensable for translation initiation; however, reducing its length promoted increased downstream initiation. Modifying start site Kozak context altered the ratio of upstream to downstream initiation, whereas mutations ...
Source: Virus Research - January 30, 2014 Category: Virology Authors: Sagar V, Murray KE Tags: Virus Res Source Type: research