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Specialty: Drugs & Pharmacology
Therapy: Cancer Therapy
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Total 97 results found since Jan 2013.
A comprehensive review on the composition, biogenesis, purification, and multifunctional role of exosome as delivery vehicles for cancer therapy
Biomed Pharmacother. 2023 Jun 29;165:115087. doi: 10.1016/j.biopha.2023.115087. Online ahead of print.ABSTRACTAll forms of life produce nanosized extracellular vesicles called exosomes, which are enclosed in lipid bilayer membranes. Exosomes engage in cell-to-cell communication and participate in a variety of physiological and pathological processes. Exosomes function via their bioactive components, which are delivered to target cells in the form of proteins, nucleic acids, and lipids. Exosomes function as drug delivery vehicles due to their unique properties of innate stability, low immunogenicity, biocompatibility, biodi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 1, 2023 Category: Drugs & Pharmacology Authors: Jian Li Ye Zhang Pei-Yu Dong Guo-Ming Yang Sangiliyandi Gurunathan Source Type: research
Targeting ZDHHC9 potentiates anti-programmed death-ligand 1 immunotherapy of pancreatic cancer by modifying the tumor microenvironment
Biomed Pharmacother. 2023 Mar 22;161:114567. doi: 10.1016/j.biopha.2023.114567. Online ahead of print.ABSTRACTImmune checkpoint blockade (ICB) therapy targeting the programmed death 1/programmed death-ligand 1 (PD-1/PD-L1) axis has achieved considerable success in treating a wide range of cancers. However, most patients with pancreatic cancer remain resistant to ICB. Moreover, there is a lack of optimal biomarkers for the prediction of response to this therapy. Palmitoylation is mediated by a family of 23 S-acyltransferases, termed zinc finger Asp-His-His-Cys-type palmitoyltransferases (ZDHHC), which precisely control vari...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 24, 2023 Category: Drugs & Pharmacology Authors: Zhiqing Lin Keke Huang Hui Guo Manli Jia Qiuqin Sun Xuhao Chen Jianmin Wu Qingqing Yao Peng Zhang Sergii Vakal Zhengzhi Zou Haiyao Gao Lei Ci Jiangfan Chen Wei Guo Source Type: research
Biomimetic cell membrane-coated nanocarriers for targeted siRNA delivery in cancer therapy
Drug Discov Today. 2023 Feb 2:103514. doi: 10.1016/j.drudis.2023.103514. Online ahead of print.ABSTRACTSmall interfering RNA (siRNA) therapeutics for cancer are a focus of increasing research interest. However, the major obstacle to their clinical application is the targeted delivery of siRNA to cancer cells at desirable levels. Cell membrane-coated nanocarriers have the advantage of combining the properties of both cell membranes and nanoparticles (NPs). In this review, we highlight the most common RNAi therapeutics and the extracellular and intracellular barriers to siRNA delivery. Moreover, we discuss clinical applicati...
Source: Drug Discovery Today - February 3, 2023 Category: Drugs & Pharmacology Authors: Xin Huang Haoyu Guo Lutong Wang Zhicai Zhang Weiyue Zhang Source Type: research
Lysosomal-mediated drug release and activation for cancer therapy and immunotherapy
Adv Drug Deliv Rev. 2022 Nov 23:114624. doi: 10.1016/j.addr.2022.114624. Online ahead of print.ABSTRACTThe development of carrier systems that are able to transport and release therapeutics to target cells is an emergent strategy to treat cancer; however, they following endocytosis are usually trapped in the endo/lysosomal compartments. The efficacy of drug conjugates and nanotherapeutics relies critically on their intracellular drug release ability, for which advanced systems responding to the unique lysosomal environment such as acidic pH and abundant enzymes (e.g. cathepsin B, sulfatase and β-glucuronidase) or equipped...
Source: Advanced Drug Delivery Reviews - November 26, 2022 Category: Drugs & Pharmacology Authors: Yinping Sun Yongjie Sha Guanhong Cui Fenghua Meng Zhiyuan Zhong Source Type: research
ASAP Recent Advancements in the Design of Nanodelivery Systems of siRNA for Cancer Therapy
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.2c00811
Source: Molecular Pharmaceutics - November 21, 2022 Category: Drugs & Pharmacology Authors: Dokkari Nagalaxmi Yadav, Mohammad Sadik Ali, Ajinkya Madhukar Thanekar, Sunil Venkanna Pogu, and Aravind Kumar Rengan Source Type: research
Inorganic nanoparticle-based advanced cancer therapies: promising combination strategies
Drug Discov Today. 2022 Sep 28:103386. doi: 10.1016/j.drudis.2022.103386. Online ahead of print.ABSTRACTInorganic nanoparticles for drug delivery in cancer treatment offer many potential advantages because they can maximize therapeutic effect through targeting ligands while minimizing off-target side-effects through drug adsorption and infiltration. Although inorganic nanoparticles were introduced as drug carriers, they have emerged as having the capacity for combined therapeutic capabilities, including anticancer effects through cytotoxicity, suppression of oncogenes and cancer cell signaling pathway inhibition. The most ...
Source: Drug Discovery Today - October 1, 2022 Category: Drugs & Pharmacology Authors: Maria John Newton Amaldoss Jia-Lin Yang Pramod Koshy Ashwin Unnikrishnan Charles C Sorrell Source Type: research
Advancement of cell-penetrating peptides in combating triple-negative breast cancer
Drug Discov Today. 2022 Sep 10:103353. doi: 10.1016/j.drudis.2022.103353. Online ahead of print.ABSTRACTExtensive research efforts have been made and are still ongoing in the search for an ideal anti-cancer therapy. Almost all chemotherapeutics require a carrier or vehicle, a drug delivery system that can transport the drug specifically to the targeted cancer cells, sparing normal cells. Cell-penetrating peptides (CPPs) provide an effective and efficient pathway for the intra-cellular transportation of various bioactive molecules in several biomedical therapies. They are now well-recognized as facilitators of intracellular...
Source: Drug Discovery Today - September 13, 2022 Category: Drugs & Pharmacology Authors: Mahak Fatima Mohammed A S Abourehab Geeta Aggarwal Gaurav K Jain Amirhossein Sahebkar Prashant Kesharwani Source Type: research
