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ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma.
This study may have important translational impacts in precise treatment of HCC. PMID: 32541921 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - June 14, 2020 Category: Drugs & Pharmacology Authors: Feng J, Lu PZ, Zhu GZ, Hooi SC, Wu Y, Huang XW, Dai HQ, Chen PH, Li ZJ, Su WJ, Han CY, Ye XP, Peng T, Zhou J, Lu GD Tags: Acta Pharmacol Sin Source Type: research

Silencing of tumor necrosis factor receptor-1 in human lung microvascular endothelial cells using particle platforms for siRNA delivery.
Abstract Acute lung injury (ALI) and its most severe manifestation, acute respiratory distress syndrome (ARDS), is a clinical syndrome defined by acute hypoxemic respiratory failure and bilateral pulmonary infiltrates consistent with edema. In-hospital mortality is 38.5% for ALI, and 41.1% for ARDS. Activation of alveolar macrophages in the donor lung causes the release of pro-inflammatory chemokines and cytokines, such as TNF-α. To determine the relevance of TNF-α in disrupting bronchial endothelial cell function, we stimulated human THP-1 macrophages with lipopolysaccharide (LPS) and used the cytokine-suppleme...
Source: Current Drug Targets - July 22, 2015 Category: Drugs & Pharmacology Authors: Bai L, Andersson HA, McConnell K, Chan D, Hernandez M, Gonzalez J, Liu X, La Francesca S, Sakamoto J, Serda RE Tags: Curr Drug Targets Source Type: research