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Resveratrol Promotes Diabetic Wound Healing via SIRT1-FOXO1-c-Myc Signaling Pathway-Mediated Angiogenesis
Conclusion: Our findings indicate that the positive role of RES in diabetic wound healing via its SIRT1-dependent endothelial protection and pro-angiogenic effects involves the inhibition of FOXO1 and the de-repression of c-Myc expression. Introduction Diabetes mellitus is a metabolic disease with an increasing incidence worldwide (Zimmet et al., 2014). The disease often leads to the development of serious complications such as microangiopathy, mainly including retinopathy, nephropathy, neuropathy, and diabetic non-healing skin ulcers (Zheng et al., 2018). Diabetic non-healing skin ulcers such as foot ulcers are ca...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

Non-canonical Notch Signaling Regulates Actin Remodeling in Cell Migration by Activating PI3K/AKT/Cdc42 Pathway
In conclusion, our research results indicate that DAPT activates PI3K/AKT/Cdc42 signaling by non-canonical Notch pathway, and the activated Cdc42 promotes the filopodia formation and inhibits lamellipodia assembly, resulting in reduced migration of breast cancer cells. The results imply that non-canonical Notch signaling may play a very important role in the rapid response of cells to the extracellular signals. Author Contributions LG, JD, and LL designed the study and wrote and revised the manuscript. LL and LZ performed most of the experiments and data analysis. SZ, X-YZ, P-XM, Y-DM, Y-YW, YC, S-JT, and Y-JZ assisted i...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of corilagin on alleviating cholestasis via farnesoid X receptor ‐associated pathways in vitro and in vivo
Conclusions and ImplicationsCorilagin exerts a protective effect in hepatocytes and can prevent the deleterious activities of intrahepatic cholestasis by stimulating FXR‐associated pathways.
Source: British Journal of Pharmacology - January 25, 2018 Category: Drugs & Pharmacology Authors: Fan Yang, Yao Wang, Gang Li, Juan Xue, Zhi ‐Lin Chen, Feng Jin, Lei Luo, Xuan Zhou, Qian Ma, Xin Cai, Hua‐Rong Li, Lei Zhao Tags: RESEARCH PAPER Source Type: research

Expression, distribution and function of kinin B1 receptor in the rat diabetic retina
Conclusion and ImplicationsThis study supports a detrimental role for kinin B1R on endothelial and glial cells in acute and advanced phases of DR. Topical application of the peptide kinin B1R antagonist R‐954 appears a feasible therapeutic approach in the treatment of DR.
Source: British Journal of Pharmacology - December 29, 2017 Category: Drugs & Pharmacology Authors: Soumaya Hachana, Menakshi Bhat, Jacques S énécal, Frédéric Huppé‐Gourgues, Réjean Couture, Elvire Vaucher Tags: RESEARCH PAPER Source Type: research

Effects of corilagin on alleviating cholestasis via FXR ‐associated pathways in vitro and in vivo
CONCLUSIONS AND IMPLICATIONSCorilagin exerts a protective effect in hepatocytes and can rescue the deleterious activities of intrahepatic cholestasis by stimulating FXR‐associated pathways.
Source: British Journal of Pharmacology - December 1, 2017 Category: Drugs & Pharmacology Authors: Fan Yang, Yao Wang, Gang Li, Juan Xue, Zhi ‐Lin Chen, Feng Jin, Lei Luo, Xuan Zhou, Qian Ma, Xin Cai, Hua‐Rong Li, Lei Zhao Tags: RESEARCH PAPER Source Type: research

G α12 facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3‐kinase‐mediated activation in a RhoA‐dependent manner
Conclusions and ImplicationsGα12 plays a crucial role in HASMC contraction via RhoA‐dependent activation of the PI3K/ROCK axis. Inhibition of RhoA activation induces bronchodilation in hPCLS, and targeting Gα12 signaling may elucidate novel therapeutic targets in asthma. These findings provide alternative approaches to the clinical management of airway obstruction in asthma.
Source: British Journal of Pharmacology - November 12, 2017 Category: Drugs & Pharmacology Authors: Edwin J Yoo, Gaoyuan Cao, Cynthia J Koziol ‐White, Christie A Ojiaku, Krishna Sunder, Joseph A Jude, James V Michael, Hong Lam, Ivan Pushkarsky, Robert Damoiseaux, Dino Di Carlo, Kwangmi Ahn, Steven S An, Raymond B Penn, Reynold A Panettieri Tags: RESEARCH PAPER Source Type: research

GPR35 mediates lodoxamide ‐induced migration inhibitory response but not CXCL17‐induced migration stimulatory response in THP‐1 cells; Is GPR35 a receptor for CXCL17?
Abstract GPR35 has long been considered an orphan G protein‐couple receptor, and although no endogenous ligand of GPR35 has been discovered, synthetic agonists and antagonists have been developed. CXCL17 (a chemokine) has been reported to be an endogenous ligand of GPR35, and it has even been suggested that it be called CXCR8 (Journal of Immunology 2015; 194:29‐33). However, no supporting report on the CXCL17‐GPR35 relation has been issued since, although GPR35 is supposed to be a potential therapeutic target in several pathologic conditions. In the present study, we applied two assay systems to explore the relations...
Source: British Journal of Pharmacology - October 25, 2017 Category: Drugs & Pharmacology Authors: Soo ‐Jin Park, Seung‐Jin Lee, So‐Yeon Nam, Dong‐Soon Im Tags: RESEARCH PAPER Source Type: research

G α12 Facilitates Carbachol‐Induced Shortening in Human Airway Smooth Muscle By Modulating Phosphoinositide 3‐Kinase‐Mediated Activation In A RhoA‐Dependent Manner
CONCLUSION AND IMPLICATIONSGα12 plays a crucial role in HASMC contraction via RhoA‐dependent activation of the PI3K/ROCK axis. Inhibition of RhoA activation induces bronchodilation in hPCLS, and targeting Gα12 signaling may elucidate novel therapeutic targets in asthma. Taken together, these findings provide alternative approaches to the clinical management of airway obstruction in asthma.
Source: British Journal of Pharmacology - September 18, 2017 Category: Drugs & Pharmacology Authors: Edwin J Yoo, Gaoyuan Cao, Cynthia J Koziol ‐White, Christie A Ojiaku, Krishna Sunder, Joseph A Jude, James V Michael, Hong Lam, Ivan Pushkarsky, Robert Damoiseaux, Dino Di Carlo, Kwangmi Ahn, Steven S An, Raymond B Penn, Reynold A Panettieri Tags: RESEARCH PAPER Source Type: research