Non-canonical Notch Signaling Regulates Actin Remodeling in Cell Migration by Activating PI3K/AKT/Cdc42 Pathway

Non-canonical Notch Signaling Regulates Actin Remodeling in Cell Migration by Activating PI3K/AKT/Cdc42 Pathway Lei Liu1,2,3, Lin Zhang1,2, Shuo Zhao4, Xu-Yang Zhao1,2, Peng-Xiang Min4, Ya-Dong Ma4, Yue-Yuan Wang4, Yan Chen1,2, Si-Jie Tang4, Yu-Jie Zhang2,4, Jun Du2,4 and Luo Gu2,4* 1Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, China 2Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China 3Department of Physiology, Xuzhou Medical University, Xuzhou, China 4Department of Physiology, Nanjing Medical University, Nanjing, China Tumor cell migration is a critical step in cancer metastasis. Over-activated Notch pathway can promote the migration of cancer cells, especially in the breast cancer. However, the underlying mechanism of non-canonical Notch signaling in modulating the migration has not yet been clearly characterized. Here we demonstrated that DAPT, a gamma secretase inhibitor, inhibited protrusion formation and cell motility, and then reduced the migration of triple-negative breast cancer cells, through increasing the activity of Cdc42 by non-canonical Notch pathway. Phosphorylation of AKT on S473 was surprisingly increased when Notch signaling was inhibited by DAPT. Inhibition of PI3K and AKT by LY294002 and MK2206, respectively, or knockdown of AKT expression by siRNA blocked DAPT-induced activation of...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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ConclusionAccording to the study results, ginseng can be potentially used for cutaneous carcinoma as a chemopreventive agent by enhancing cell-mediated immunity and maintaining redox homeostasis with multiple components, targets and links.
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research
Publication date: Available online 21 May 2019Source: Canadian Journal of CardiologyAuthor(s): Celine Gallagher, Jeroen Hendriks, Melissa E. Middeldorp, Adrian D. Elliott, Dennis H. Lau, Prashanthan Sanders
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 21 May 2019Source: Canadian Journal of CardiologyAuthor(s): Mike Pryzbek, Maureen MacDonald, Paul Stratford, Angelica McQuarrie, Julie Richardson, Robert McKelvie, Ada TangAbstractBackgroundDespite known associations between fitness and recurrent cardiovascular events, changes in cardiorespiratory fitness (CRF) and muscle strength with long-term cardiac rehabilitation (CR) have not been extensively examined. The purpose of this study was to: 1) Examine changes in CRF and muscle strength associated with long-term CR program enrollment in men, and 2) Compare these changes to previously publ...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
This study recruited 498 STEMI patients post percutaneous coronary intervention (PCI), 40 with stable angina pectoris (SAP) and 137 healthy participants. Plasma MIF levels were measured at admission and after PCI. The primary endpoints were in-hospital mortality and major adverse cardio- and/or cerebro-vascular events (MACE/MACCE) during hospitalization and 3.2-year follow-up period.ResultsAdmission MIF levels were elevated in 88.4% STEMI patients over the upper reference limit of healthy controls and it was 3-7 folds higher than that in SAP and control groups (122±61 vs. 39±19 vs. 17±8 ng/mL, P
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
We describe some of the perspectives in the literature around second valve replacement for PUID with IE, arguing that moralistic arguments are not based on evidence and perpetuate the stigma experienced by PUID seeking treatment for IE. Finally, we explore the role of substance use interventions in the treatment of PUID with IE, and advocate for further evidence. PUID with IE are a highly stigmatized patient subgroup for whom best practice management strategies are not always implemented, emphasizing the need for further research and advocacy.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 20 May 2019Source: Canadian Journal of CardiologyAuthor(s): Makoto Mori, Clancy Mullan, Syed Usman Bin Mahmood, Sameh Yousef, Keith J. Pelletier, Abeel A. Mangi, Arnar GeirssonAbstractBackgroundPatient characteristics, trends in the management strategy, and outcomes of patients with constrictive pericarditis have not been characterized at the national scale.MethodsAnnual trends of patients admitted to hospitals in the U.S. with constrictive pericarditis was evaluated using the National Inpatient Sample (NIS) dataset between 2005-2014. Poisson regression models adjusting for the U.S. censu...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 20 May 2019Source: Canadian Journal of CardiologyAuthor(s): Hung Q. Ly, Mohamed Nosair, Raymond CartierABSTRACTOptimal revascularization in severe ischemic heart disease (SIHD) is addressed in all clinical guidelines. With an aging patient population, a growing challenge remains the management of SIHD patients deemed ineligible for surgical revascularization, the so-called surgical turndown patient. The status of surgical ineligibility remains associated with worse clinical outcomes. As the general population grows older and comorbidities increase, this subset of SIHD will likely increase...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
This study aimed to assess survival after TARE and to identify potential prognostic factors in this patient population. METHODS: Patients with unresectable and chemorefractory CRCLM treated with TARE at our institution between February 2006 and September 2015 were included in the study. Survival rate, hepatic tumor response, and potential prognostic factors were analyzed. RESULTS: In the 43 study patients, the mean follow-up was 15.0 ± 14.2 months, with a median survival of 13.0 months and 1-, 2-, 3-, 4-, and 5-year survival rates of 52.1%, 24.9%, 21.4%, 21.4%, and 7.1%, respectively. The mean activity of yt...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
Authors: Ballestri S, Nascimbeni F, Lugari S, Lonardo A, Francica G Abstract INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) spans steatosis through nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis and hepatocellular carcinoma (HCC). NAFLD carries an increased risk of cardio-metabolic and liver-related events accounting for a substantial economic burden. Given that the natural history of NAFLD is critically dependent on the stage of fibrosis, non-invasively identifying the subgroup of patients at a higher risk of progressive disease is key. Areas covered: This review highlights the recent development...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
Conclusion: PD-L1 expression in microenvironment predicted better PFS. The combination of EGFR inhibitors and ICB could help deepening the knowledge about the interrelations between the EGFR and PD-1/PD-L1 pathways.Oncology
Source: Oncology - Category: Cancer & Oncology Source Type: research
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