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Specialty: Drugs & Pharmacology
Condition: Mitochondrial Disease
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Total 80 results found since Jan 2013.
Ginsenoside Rd attenuates myocardial ischemia injury through improving mitochondrial biogenesis via WNT5A/Ca < sup > 2+ < /sup > pathways
Eur J Pharmacol. 2023 Sep 1;957:176044. doi: 10.1016/j.ejphar.2023.176044. Online ahead of print.ABSTRACTGinsenoside Rd, one of the main active components in ginseng, exerts various biological activities. However, its effectiveness on myocardial ischemia injury and its potential mechanism need further clarification. The model of isoproterenol (ISO)-induced myocardial ischemia injury (MI) mice and cobalt chloride (CoCl2)-induced cardiomyocytes injury were performed. Ginsenoside Rd significantly alleviated MI injury, as evidenced by ameliorated cardiac pathological features and improved cardiac function. Simultaneously, gins...
Source: European Journal of Pharmacology - September 3, 2023 Category: Drugs & Pharmacology Authors: Zekun Cui Lifei Gu Tao Liu Yining Liu Boyang Yu Junping Kou Fang Li Kun Yang Source Type: research
Hydrogen sulfide promoted retinoic acid-related orphan receptor α transcription to alleviate diabetic cardiomyopathy
Biochem Pharmacol. 2023 Aug 15:115748. doi: 10.1016/j.bcp.2023.115748. Online ahead of print.ABSTRACTDiabetic cardiomyopathy (DCM) is one serious and common complication in diabetes without effective treatments. Hydrogen sulfide (H2S) fights against a variety of cardiovascular diseases including DCM. Retinoic acid-related orphan receptor α (RORα) has protective effects on cardiovascular system. However, whether RORα mediates the protective effect of H2S against DCM remains unknown. The present research was to explore the roles and mechanisms of RORα in H2S against DCM. The study demonstrated that H2S donor sodium hydro...
Source: Biochemical Pharmacology - August 17, 2023 Category: Drugs & Pharmacology Authors: Shuping Zhang Jieru Shen Yu Zhu Yangyang Zheng Wenqin San Danyi Cao Yun Chen Guoliang Meng Source Type: research
TIMELESS promotes the proliferation and migration of lung adenocarcinoma cells by activating EGFR through AMPK and SPHK1 regulation
CONCLUSIONS: Our study revealed that siTIM could inhibited EGFR activation through activating AMPK and inhibiting SPHK1 expression, as well as influencing mitochondrial function and alter the ATP level; TIM's high expression in LUAD is an important factor and a potential key target in LUAD.PMID:37433364 | DOI:10.1016/j.ejphar.2023.175883
Source: European Journal of Pharmacology - July 11, 2023 Category: Drugs & Pharmacology Authors: Houqing Yin Zequn Wang Dan Wang Muhadaisi Nuer Mengyuan Han Peng Ren Shanwu Ma Chutong Lin Jingjing Chen Haocheng Xian Dongmei Ai Xuejun Li Shaohua Ma Zhiqiang Lin Yan Pan Source Type: research
Curcumin protects against the age-related hearing loss by attenuating apoptosis and senescence via activating Nrf2 signaling in cochlear hair cells
This study is the first to demonstrate that curcumin can prevent oxidative stress-induced auditory hair cell degeneration through Nrf2 activation, highlighting its potential therapeutic value in preventing ARHL.PMID:37334787 | DOI:10.1016/j.bcp.2023.115575
Source: Biochemical Pharmacology - June 19, 2023 Category: Drugs & Pharmacology Authors: Ning Li Xirui Yan Weiling Huang Min Chu Yang Dong Haiyan Song Yinting Peng Jianrong Shi Qing Liu Source Type: research
The application of nucleic acid nanomaterials in the treatment of mitochondrial dysfunction
Curr Drug Metab. 2023 Jun 14. doi: 10.2174/1389200224666230614115655. Online ahead of print.ABSTRACTMitochondrial dysfunction is considered highly related to the development and progression of diseases, including cancer, metabolism disturbance, and neurodegeneration. Traditional pharmacological approach for mitochondrial dysfunction treatment has off-target and dose-dependent side effects, which leads to the emergence of mitochondrial gene therapy by regulating coding or noncoding genes by using nucleic acid sequences such as oligonucleotides, peptide nucleic acids, rRNA, siRNA, etc. To avoid size heterogeneity and potenti...
Source: Current Drug Metabolism - June 15, 2023 Category: Drugs & Pharmacology Authors: Lan Yao Hai Qing Tao Zhang Source Type: research
