• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Cutaneous wound healing in diabetic mice is improved by topical mineralocorticoid receptor blockade
Skin ulcers resulting from impaired wound healing are a serious complication of diabetes. Unresolved inflammation, associated with the dysregulation of both the phenotype and function of macrophages, is involved in the poor healing of diabetic wounds. Here, we report that topical pharmacological inhibition of the mineralocorticoid receptor (MR) by canrenoate or MR siRNA can resolve inflammation to improve delayed skin wound healing in diabetic mouse models; importantly, wounds from normal mice are unaffected.
Source: Journal of Investigative Dermatology - July 2, 2019 Category: Dermatology Authors: Van Tuan Nguyen, Nicolette Farman, Roberto Palacios-Ramirez, Maria Sbeih, Francine Behar-Cohen, S élim Aractingi, Frederic Jaisser Tags: Original Article Source Type: research

1421 Topical glucosylceramide synthase inhibitor speeds wound healing in diabetic mice
Non-healing foot ulcers develop in 10-25% of type 2 diabetics. We have previously shown that reduction in ganglioside GM3 by GM3 synthase (GM3S) gene knockdown or topically applied GM3S siRNA nanoconstructs normalizes wound healing in diet-induced obese (DIO) diabetic mice. The mechanism is reversal of IGF-1 and EGF receptor resistance, leading to accelerated keratinocyte migration and normal cutaneous innervation. A small molecule inhibitor of glucosylceramide synthase (GCSI) also reduces GM3 and, given GCSI's small size, could be moved towards clinical trials of topical application should it replicate the ameliorative ef...
Source: Journal of Investigative Dermatology - April 27, 2018 Category: Dermatology Authors: I. Fogel, M.I. Guerrero-Zayas, X.Q. Wang, X. Cheng, A. Paller Tags: Tissue Regeneration and Wound Healing Source Type: research

Sirtuin‐6 deficiency exacerbates diabetes‐induced impairment of wound healing
Abstract Delayed wound healing is one of the major complications in diabetes and is characterized by chronic proinflammatory response, and abnormalities in angiogenesis and collagen deposition. Sirtuin family proteins regulate numerous pathophysiological processes, including those involved in promotion of longevity, DNA repair, glycolysis and inflammation. However, the role of sirtuin 6 (SIRT6), a NAD+‐dependent nuclear deacetylase, in wound healing specifically under diabetic condition remains unclear. To analyse the role of SIRT6 in cutaneous wound healing, paired 6‐mm stented wound was created in diabetic db/db mice...
Source: Experimental Dermatology - August 18, 2015 Category: Dermatology Authors: Rajarajan A. Thandavarayan, Venkata Naga Srikanth Garikipati, Darukeshwara Joladarashi, Sahana Suresh Babu, Prince Jeyabal, Suresh K. Verma, Alexander R. Mackie, Mohsin Khan, Somasundaram Arumugam, Kenichi Watanabe, Raj Kishore, Prasanna Krishnamurthy Tags: Original Article Source Type: research

Sirtuin‐6 deficiency exacerbates diabetes induced impairment of wound healing
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - May 23, 2015 Category: Dermatology Authors: Rajarajan A Thandavarayan, Venkata Naga Srikanth Garikipati, Joladarashi Darukeshwara, Sahana Suresh Babu, Prince Jeyabal, Suresh K Verma, Alexander R Mackie, Mohsin Khan, Somasundaram Arumugam, Kenichi Watanabe, Raj Kishore, Prasanna Krishnamurthy Tags: Regular Article Source Type: research