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Nestin contributes to laser choroidal and retinal neovascularization
CONCLUSIONS: Our results confirmed the presence of nestin in glial (e.g., astrocytes), reactive Müller, and endothelial cells. They demonstrated their critical involvement in a rat model of retinal and choroidal neovascularization experimentally induced using ocular laser impacts.PMID:36284669 | PMC:PMC9514549
Source: Molecular Vision - October 26, 2022 Category: Molecular Biology Authors: Sofiane Miloudi Maud Valensi Mohamed El Sanharawi Marc M Abitbol Francine Behar-Cohen Claudine Versaux-Botteri Source Type: research

Expression and activation of the ketone body receptor HCAR2/GPR109A promotes preservation of retinal endothelial cell barrier function
Exp Eye Res. 2022 May 29:109129. doi: 10.1016/j.exer.2022.109129. Online ahead of print.ABSTRACTPreservation of retinal barrier function is critical to maintenance of retinal health. Therefore, it is not surprising that loss of barrier integrity is a pathologic feature common to degenerative retinal diseases such as diabetic retinopathy. Our prior studies demonstrate the importance of hydroxycarboxylic acid receptor 2/GPR109A (HCAR2/GPR109A) expression in the retinal pigment epithelium (RPE) to outer retinal barrier integrity. However, whether HCAR2/GPR109A is expressed in retinal endothelial cells and has a similar relati...
Source: Experimental Eye Research - June 1, 2022 Category: Opthalmology Authors: Ammar A Abdelrahman Folami L Powell Ravirajsinh N Jadeja Malita A Jones Menaka C Thounaojam Manuela Bartoli Mohamed Al-Shabrawey Pamela M Martin Source Type: research