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Suppression of Cell Proliferation and Macrophage Infiltration with Localized siRNA Delivery in a Murine Model of Intimal Hyperplasia
Intimal hyperplasia limits the durability of peripheral vascular interventions and is associated with cell proliferation and macrophage infiltration. We use an in vivo rat carotid angioplasty model to evaluate inhibition of intimal hyperplasia with localized siRNA delivery targeting Thrombospondin-2 (TSP2) and evaluate its impact on cell proliferation (Ki-67) and macrophage infiltration (CD68).
Source: Journal of Vascular Surgery - May 19, 2022 Category: Surgery Authors: Jennifer R. Li, Max Zhu, Patric Liang, Kimberly Piper, Mauricio Contreras, Leena Pradhan-Nabzdyk, Frank LoGerfo Tags: PC: Poster Competition Source Type: research

Delivery of Thrombospondin-2 Small Interfering RNA for Suppression of Intimal Hyperplasia
Treatments of peripheral arterial disease, which affects>8.5 million individuals in the United States, include angioplasty and stenting and graft bypass. However, these have been limited by the pervasive development of intimal hyperplasia, which leads to in-stent restenosis and reduced graft patency. We propose a novel technique to suppress the progression of intimal hyperplasia using bioengineered hydrogels (ClickGels) for localized small interfering RNA (siRNA) delivery and suppression of thrombospondin-2 (TSP2), an upregulated gene of intimal hyperplasia, in an in vivo rat carotid angioplasty model.
Source: Journal of Vascular Surgery - August 24, 2021 Category: Surgery Authors: Jennifer R. Li, Kimberly Piper, Patric Liang, Max Zhu, Mauricio Contreras, Alexander Stafford, David Mooney, Leena Pradhan-Nabzdyk, Frank Logerfo Tags: PC: Poster Competition Source Type: research